1.14.14.47: nitric-oxide synthase (flavodoxin)

This is an abbreviated version!
For detailed information about nitric-oxide synthase (flavodoxin), go to the full flat file.

Reaction

2 L-arginine + 2 reduced flavodoxin + 2 O2 = 2 Nomega-hydroxy-L-arginine + 2 oxidized flavodoxin + 2 H2O

Synonyms

bNOS, GK1676, nitric oxide synthetase, NO synthase, NOS, SANOS, YumC

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.47 nitric-oxide synthase (flavodoxin)

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Results	in table
1	Activating Compound
2143	AA Sequence
2	Application
10	Cloned(Commentary)
17	Cofactor
11	Crystallization (Commentary)
2	General Information
6	IC50 Value
14	Inhibitors
1	Ki Value [mM]
3	KM Value [mM]
1	Localization
4	Metals/Ions
1	Molecular Weight [Da]
155	Organism
3	Pathway
8	PDB ID
25	Protein Variants
3	Purification (Commentary)
3	Reaction
34	Reference
1	Specific Activity [micromol/min/mg]
26	Substrates and Products (Substrate)
2	Subunits
10	Synonyms
1	Systematic Name
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.14.47 - nitric-oxide synthase (flavodoxin)

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SYSTEMATIC NAME

IUBMB Comments

L-arginine,reduced-flavodoxin:oxygen oxidoreductase (nitric-oxide-forming)

Binds heme (iron protoporphyrin IX) and tetrahydrobiopterin. The enzyme, found in bacteria and archaea, consist of only an oxygenase domain and functions together with bacterial ferredoxins or flavodoxins. The orthologous enzymes from plants and animals also contain a reductase domain and use only NADPH as the electron donor (cf. EC 1.14.13.39).