1.14.14.47: nitric-oxide synthase (flavodoxin)
This is an abbreviated version!
For detailed information about nitric-oxide synthase (flavodoxin), go to the full flat file.
Word Map on EC 1.14.14.47
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1.14.14.47
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familia
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latino
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pacientes
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farmworker
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grupos
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condom
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analysis
- 1.14.14.47
-
familia
-
latino
-
pacientes
-
farmworker
-
grupos
-
condom
- analysis
Reaction
2 L-arginine + 2 reduced flavodoxin + 2 O2 = 2 Nomega-hydroxy-L-arginine + 2 oxidized flavodoxin + 2 H2O
Synonyms
bNOS, GK1676, nitric oxide synthetase, NO synthase, NOS, SANOS, YumC
ECTree
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Metals Ions
Metals Ions on EC 1.14.14.47 - nitric-oxide synthase (flavodoxin)
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Iron
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in the presence of L-arginine and tetrahydrofolate, wild-type and mutants W66F and W66H exist in the typical Fe(III) high-spin configuration
Iron
resonance Raman and ATR-FTIR spectroscopic study. The resting native ferric NOS exhibits an exclusive five-coordinate high-spin iron status. The nyFe-CO and nyCO mode frequencies indicate a weaker electrostatic interaction between Arg and CO. NOS is characterized by a stronger Fe-S bond, a lower ny4 frequency, and a negative shift in the nyFe-CO/nyCO correlation. The effects of tetrahydrobioptein on NOS heme structure are minor compared to the ones reported on the enzyme from Mus musculus
Iron
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in the substrate-free form, the Fe-Cys stretching mode is detected at 342.5 per cm, similar to that of Bacillus subtilis NOS. The binding of L-Arg and N-hydroxy-L-arginine brings about a small decrease and increase in the Fe-Cys stretching frequency, respectively
Iron
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the enzyme's reductase domain utilizes a 2Fe2S cluster for electron transfer