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1.14.14.117: aflatoxin B synthase

This is an abbreviated version!
For detailed information about aflatoxin B synthase, go to the full flat file.

Reaction

8-O-methyldihydrosterigmatocystin
+ 2 [reduced NADPH-hemoprotein reductase] + 2 O2 =
Aflatoxin B2
 + 2 [oxidized NADPH-hemoprotein reductase] +
H2O
 +
methanol
 +
CO2

Synonyms

aflQ, EC 1.14.13.175, ordA

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.117 aflatoxin B synthase

Engineering

Engineering on EC 1.14.14.117 - aflatoxin B synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A143S
the mutation affects enzymatic activity (approximately 50% of the enzyme activity which converts O-methylsterigmatocystin to aflatoxin B1 is lost)
H400L
the mutation results in a loss of the monooxygenase activity
I528Y
the mutation does not affect enzymatic activity
A143S
-
the mutation affects enzymatic activity (approximately 50% of the enzyme activity which converts O-methylsterigmatocystin to aflatoxin B1 is lost)
-
H400L
-
the mutation results in a loss of the monooxygenase activity
-
I528Y
-
the mutation does not affect enzymatic activity
-