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1.14.11.69: [histone H3]-trimethyl-L-lysine36 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-trimethyl-L-lysine36 demethylase, go to the full flat file.

Word Map on EC 1.14.11.69

Reaction

a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
+ 2 2-oxoglutarate + 2 O2 =
a [histone H3]-N6-methyl-L-lysine36
 + 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

AN1060, CG15835, CG33182, dKDM4A, Dmel\Kdm4A, DNA damage-responsive transcriptional repressor, H3K36 demethylase, H3K36 histone demethylase, H3K9/36me3 lysine demethylase, histone demethylase JmjD2A, histone H3 demethylase, histone H3K36 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone lysine demethylase, JHDM3A, JHDM3B, JmjC demethylase, JmjC histone lysine demethylase, JmjC protein, JMJD-2, JMJD2A, JMJD2A demethylase, JMJD2B, JMJD2C, jumonji domain containing 2A, JumonjiC-domain-containing histone demethylase, JumonjiD2A, KDM, KDM4, KDM4A, KDM4A demethylase, KDM4A lysine demethylase, KDM4A,, KDM4A/JMJD2A, KDM4B, Kdm4c, KdmA, LD33386, lysine trimethyl-specific JmjC histone demethylase, lysine-specific demethylase 4A, More, Rph1, Rph1/KDM4, trimethyllysine-specific histone demethylase, trimethyllysine-specific JmjC HDM

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.69 [histone H3]-trimethyl-L-lysine36 demethylase

Cloned

Cloned on EC 1.14.11.69 - [histone H3]-trimethyl-L-lysine36 demethylase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
characterization of dKDM4A alleles, and the dKDM4A genomic locus, the dKDM4A locus contains four exons, overview. Quantitative RT-PCR of dKDM4A expression analysis of wild-type and mutant enzymes in larvae
-
expression of wild-type and mutant dKDM4A in Spodoptera frugiperda Sf21 cells using baculovirus transfection
expresssion in NIH3T3 and HEK293T cells
gene CG15835 or Kdm4A, sequence comparisons, recombinant overexpression of FLAG-tagged wild-type and mutant enzymes in S2 cells
gene CG33182, sequence comparisons, recombinant overexpression of FLAG-tagged enzyme in S2 cells
gene dkdm4a, expression of FLAG-tagged wild-type and V423A mutant enzymes
-
gene KDM4A, DNA and amino acid sequence determination and analysis, quantitative PCR expression analysis and sequence comparisons
gene KDM4A, phylogenetic analysis, recombinant expression of N-terminally His-tagged KDM4A catalytic domain in Escherichia coli
gene KDM4A, real-time RT-PCR enzyme expression analysis
gene KDM4A, recombinant expression of EGFP-tagged full-length and truncated enzymes versions in U2-O2 cells
gene KDM4A, recombinant expression of FLAG-tagged JMJD2A in Spodoptera frugiperda Sf9 cells
gene KDM4A, recombinant expression of GFP-tagged enzyme-deficient mutant and of point mutants in fibroblasts, overexpression of JmjD2A under the control beta-actin promoter in chicken fibroblasts specifically depletes H3K9me3 and H3K36me3
gene KDM4A, recombinant expression of His-tagged enzyme in Escherichia coli strain Rosetta 2 (DE3)
gene KDM4A, recombinant expression of His-tagged KDM4A residues 1-359 in Escherichia coli strain BL21 Codon-Plus-Ril from plasmid pNIC28-Bsa4
gene KDM4A, recombinant expression of N-terminally His-tagged enzyme in Escherichia coli
gene KDM4A, recombinant overexpression in U2O2 cells, recombinant expression of N-terminally FLAG-tagged KDM4A or KDM4A mutant H188A in HeLa cells, recombinant expression of N-terminally His6-tagged truncated KDM4A1-359 in Escherichia coli strain BL21(DE3)
gene KDM4A, transient recombinant overexpression in RPE cells
gene KDM4A/Jmjd2a, the loci encoding Jmjd2a and Jmjd2c are both located on chromosome 4 about 40 MB apart and are thus expected to co-segregate with a frequency related to the rate of meiotic recombination
gene KDM4B or Jmjd2b, real-time quantitative PCR expression analysis
gene KDM4B, phylogenetic analysis, recombinant expression of N-terminally His-tagged KDM4B catalytic domain in Escherichia coli
gene KDM4B, recombinant isozyme expression in U2OS-TetON stable cell line that conditionally expresses the fusion protein EGFP-KDM4B
gene KDM4C, phylogenetic analysis, recombinant expression of N-terminally His-tagged KDM4C catalytic domain in Escherichia coli
gene KDM4C, recombinant isozyme expression in U2OS-TetON stable cell line that conditionally expresses the fusion protein EGFP-KDM4C, recombinant expression of EGFP-tagged full-length and truncated, and mutant enzymes versions
gene KDM4C/Jmjd2c, the loci encoding Jmjd2a and Jmjd2c are both located on chromosome 4 about 40 MB apart and are thus expected to co-segregate with a frequency related to the rate of meiotic recombination
gene kdmA or AN1060, phylogenetic analysis