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EC Number
IC50 Value
IC50 Value Maximum
Inhibitor
Commentary
Reference
2.3.1.32
-999
-
more
10, 25, 50 microM inhibit FLAG-tagged recombinant PCAF in vitro with an IC50 beyond 50 microM with purified human HeLa core histone as substrate
704529
2.3.1.32
-999
-
more
Hep-G2 hepatocarcinoma cells: with 5 microM plumbagin 50% reduction of histone H3 acetylation, with 25 microM 90% reduction, significant overall acetylation status of histones, prominent reduction in H3 and H4, immunofluorescence analysis (anti-acetylated histone H3 polyclonal antibodies) of HeLa cells (treated with deacetylase inhibitors to induce histone acetylation) confirm the inhibitory effect of plumbagin with 5 microM inhibitor, with 25 microM almost complete reduction in acetylation level
704529
2.3.1.32
-999
-
more
significant decrease of histone acetylation in plumbagin treated mouse liver in vivo 6 h after intraperitoneal injection of 25 mg plumbagin/kg body mass
704529
2.3.1.32
0.002
-
Plumbagin
recombinant minimal HAT domain of p300
704529
2.3.1.32
0.02
-
Plumbagin
recombinant full-length p300
704529
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