EC Number   |
Application |
Reference |
|---|
    2.3.1.57 | analysis |
colorimetric assay for monitoring enzyme SSAT1 activity in zebrafish using a 412-nm absorption spectrum in the presence of Ellman's reagent. The method is cost-effective and simple and also applicable to detect the cellular enzyme activity |
718567 |
| 2.3.1.57 | drug development |
SSAT may also be a useful target in diseases other than cancer |
701622 |
| 2.3.1.57 | medicine |
activation of the enzyme by aspirin and different non-steroidal anti-inflammatory drugs may be a common property of non-steroidal anti-inflammatory drugs that plays an important role in their chemopreventive actions in colorectal cancer |
671847 |
| 2.3.1.57 | medicine |
amantadine can be used to determine enzyme cellular activity by measuring excretion of N1-acetylamantadine which may indicate the presence of cancer |
756851 |
| 2.3.1.57 | medicine |
compared with wild-typet mice, the enzyme-deficient mice subjected to endotoxic acute kidney injury have less severe kidney damage as indicated by better preservation of kidney function. Animals treated with MDL72527, an inhibitor of both polyamine oxidase and spermine oxidase, show significant protection against endotoxin-induced acute kidney injury. Increased polyamine catabolism may contribute to kidney damage through generation of by-products of polyamine oxidation |
718544 |
| 2.3.1.57 | medicine |
development of SSAT induction strategies to circumvent the ability of tumor cells to escape the antitumor activity of polyamine inhibitors such as alpha-difluoromethylornithine by salvaging exogenous polyamines |
487266 |
| 2.3.1.57 | medicine |
in kidneys subjected to ischemia-reperfusion injury, one mechanism through which increased expression of SSAT may cause cellular injury and organ damage is through induction of DNA damage and the disruption of cell cycle |
671226 |
| 2.3.1.57 | medicine |
induction of enzyme may be critical for the inhibition of tumor cell growth |
487263 |
| 2.3.1.57 | medicine |
logical target for tumor prevention |
487270 |
| 2.3.1.57 | medicine |
the ability of polyamine analogues to induce N1SSAT activity correlates with the ability to inhibit growth and viability of human tumor-derived cells |
487264 |
