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Literature summary for 2.3.1.57 extracted from

  • Maksymiuk, A.W.; Sitar, D.S.; Ahmed, R.; Cheng, B.; Bach, H.; Bagchi, R.A.; Aroutiounova, N.; Tappia, P.S.; Ramjiawan, B.
    Spermidine/spermine N1-acetyltransferase-1 as a diagnostic biomarker in human cancer (2018), Future Sci. OA, 4, FSO345 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.57

Application

Application Comment Organism
medicine amantadine can be used to determine enzyme cellular activity by measuring excretion of N1-acetylamantadine which may indicate the presence of cancer Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + amantadine Homo sapiens
-
 CoA + N1-acetylamantadine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
breast cancer cell
-
 Homo sapiens
-
bronchial epithelial cell
-
 Homo sapiens
-
LNCaP cell
-
 Homo sapiens
-
lung cancer cell
-
 Homo sapiens
-
mammary epithelial cell
-
 Homo sapiens
-
additional information the enzyme is not detected in noncancerous human cells Homo sapiens
-
prostate adenocarcinoma cell
-
 Homo sapiens
-
prostate epithelium cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + amantadine
-
 Homo sapiens CoA + N1-acetylamantadine
-
 ?

Synonyms

Synonyms Comment Organism
spermidine/spermine N1-acetyltransferase-1
-
 Homo sapiens
SSAT-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens high levels of enzyme expression are measured in tumor human cell lines, and in breast, prostate and lung tumor tissue. Increases in enzyme protein contents and gene expression in primary tumors is linked to a concomitant higher level of N1-acetylamantadine in urine of cancer patients upon ingestion of amantadine up

General Information

General Information Comment Organism
physiological function the enzyme plays a critical role in cell growth Homo sapiens