   1.14.11.67 | medicine |
paclitaxel-resistant lung adenocarcinoma PTX-Calu-3 cells show significantly higher IC50 value (7 microM) upon paclitaxel treatxadment than lung adenocarcinoma SK-LI-1 (3.6 nM), Calu-3 (4.3 nM), and A549 (4.5 nM) cells. Expression of KDM5A and P-glycoprotein are significantly higher in PTX-Calu-3 cells compared to SK-LI-1, Calu-3, and A549 cells. A significantly higher number of PTX-Calu-3 cells are inxadvasive and motile compared to SK-LI-1, Calu-3, and A549 cells. A significantly higher expression of KDM5A is observed in lung adenocarcixadnoma patients' samples compared with adjacent normal tissues as well as in PTX-Calu-3 cells |
763832 |
