Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.67 extracted from

  • Wu, L.; Cao, J.; Cai, W.; Lang, S.; Horton, J.; Jansen, D.; Liu, Z.; Chen, J.; Zhang, M.; Mott, B.; Pohida, K.; Rai, G.; Kales, S.; Henderson, M.; Hu, X.; Jadhav, A.; Maloney, D.; Simeonov, A.; Zhu, S.; Iwasaki, A.; Hall, M.; Cheng, X.; Shadel, G.; Yan, Q
    KDM5 histone demethylases repress immune response via suppression of STING (2018), PLoS Biol., 16, e2006134 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.67

Application

Application Comment Organism
medicine in human tumors, KDM5B expression is inversely associated with STING expression in multiple cancer types, with the level of intratumoral CD8+ T cells, and with patient survival in cancers with a high level of cytosolic DNA, such as human papilloma virus-positive head and neck cancer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P41229 isoform KDM5C
-
Homo sapiens Q9UGL1 isoform KDM5B
-

Source Tissue

Source Tissue Comment Organism Textmining
BT-474 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
SK-BR-3 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
KDM5B
-
 Homo sapiens
KDM5C
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the expression of STING, i.e. cyclic GMP-AMP synthase stimulator of interferon genes, is epigenetically suppressed by the histone H3K4 lysine demethylases KDM5B and KDM5C. The induction of STING expression by KDM5 blockade triggers a robust interferon response in a cytosolic DNA-dependent manner in breast cancer cells, resulting in resistance to infection by DNA and RNA viruses Homo sapiens