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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.62diagnostics 17beta-HSD1 is highly expressed in breast and ovary tissues and represents a prognostic marker for the tumor progression and survival of patients with breast cancer and other estrogen-dependent tumors 740542
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.62diagnostics a high HSD17B1 to HSD17B2 ratio, as well as high HSD17B1 on its own is associated with worse prognosis and increased risk of recurrence in patients with ERalpha-positive tumors. An increased copy number of the HSD17B1 gene is correlated with decreased breast cancer survival 762074
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.62diagnostics the expression of 17beta-hydroxysteroid dehydrogenases 1 and 2 alone and in combination predicts outcome of patients with breast cancer 762074
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.62diagnostics the mouse monoclonal antibody for AKR1C3, 10B10, is highly specific and sensitive for detecting AKR1C3 expression including patient samples. The proper detection of AKR1C3 expression is critical for therapeutics targeting AKR1C3, 10B10 will be a valuable tool in clinic for AKR1C3 precision therapy. 10B10 is specific to AKR1C3 protein and has a very low cross-activity against other AKR1 proteins 762480
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.62drug development several 17beta-HSD isozymes are targets for drug development with importance in cancer, metabolic diseases, neurodegeneration and possibly immunity 675983
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.62drug development the enzyme constitutes an interesting therapeutic target for estrogen-dependent diseases 760541
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.62drug development the enzyme is considered a promising drug target against estrogen-dependent cancers 740542
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.62medicine 17beta-HSD1 inhibitors such as STX1040 may provide a treatment for hormone-dependent breast cancer 687146
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.62medicine 17beta-HSD1 is an attractive target for the treatment of mammary tumours 685552
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.62medicine 17beta-HSD1 is overexpressed in many breast tumors. Thus, it is an attractive target for the treatment of these diseases 688272
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