Literature summary for 1.1.1.62 extracted from

Liu, J.; He, P.; Lin, L.; Zhao, Y.; Deng, W.; Ding, H.; Li, Q.; Wang, Z.
Characterization of a highly specific monoclonal antibody against human aldo-keto reductase AKR1C3 (2019), Steroids, 143, 73-79 .

Search for more literature for 1.1.1.62

Application

Application	Comment	Organism
diagnostics	the mouse monoclonal antibody for AKR1C3, 10B10, is highly specific and sensitive for detecting AKR1C3 expression including patient samples. The proper detection of AKR1C3 expression is critical for therapeutics targeting AKR1C3, 10B10 will be a valuable tool in clinic for AKR1C3 precision therapy. 10B10 is specific to AKR1C3 protein and has a very low cross-activity against other AKR1 proteins	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P42330	-	-

Synonyms

Synonyms	Comment	Organism
AKR1C3	-	Homo sapiens
type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	expression is relatively low in most tissues and high in prostate and mammary glands in regulating androgen and estrogen levels. In many cancers, overexpression of AKR1C3 is observed	up

General Information

General Information	Comment	Organism
metabolism	besides as a biomarker in cancer, AKR1C3 is important in the reduction of steroids and prostaglandins, and function as part of a chemical barrier to defend the body from intrusion of toxic chemicals	Homo sapiens

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Release 2023.1 (January 2023)