Cloned (Comment) | Organism |
---|---|
gene CYP8B1, expression analysis in liver tissues of wild-type, regulation of gene expression, overview | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of CYP8B1 null mice which show increased expression of cholesterol 7alpha-hydroxylase, CYP7A1, EC 1.14.13.17 | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | cholate supresses enzyme expression | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | Mus musculus | the enzyme is necessary for the synthesis of cholic acid | 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | enzyme expression pattern within the liver architecture, zonal distribution pattern, overview | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is necessary for the synthesis of cholic acid | Mus musculus | 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP8B1 | - |
Mus musculus |
sterol 12alpha-hydroxylase | - |
Mus musculus |