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5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
5beta-cholestane-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestane-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
7alpha-hydroxycholest-4-en-3-one + NADH + H+ + O2
7alpha,12alpha-dihydroxycholest-4-en-3-one + NAD+ + H2O
-
reaction with NADH shows 15% of the activity with NADPH
-
-
?
7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2
7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
additional information
?
-
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
activation of farnesoid X receptor FXR initiates a feedback regulatory loop via induction of small heterodimer partner, SHP, which suppresses liver receptor homolog 1, LRH-1, and HNF4alpha dependent expression of sterol 12alpha hydroxylase, CYP8B1, overview
-
-
?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
the enzyme is involved in bile acid synthesis, repression of bile acid synthesis and induction of basolateral bile acid export may represent adaptive mechanisms to limit bile acid burden in chronic cholestasis, but the changes do not sufficiently counteract cholestatic liver damage, overview
-
-
?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
a key step in bile acid synthesis
-
-
?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2
7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
-
-
-
-
?
7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2
7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
-
-
-
-
?
7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2
7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
-
microsomal enzyme activity was markedly elevated by starvation or streptozotocin administration to the animals
-
-
?
7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2
7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
-
-
-
-
?
7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2
7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
-
key enzyme for the formation of cholic acid
-
-
?
7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2
7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
-
NADPH is the preferred electron source
-
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
thyroid hormone triiodothyronine has a regulatory function on the enzyme expressiona and bile acid metabolism, overview
-
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
dietary cholsterol and cholic acid have an influence of enzyme regulation
-
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
the enzyme channels bile acid precursors into cholic acid, but is not affected on mRNA and protein levels by increased cholic acid or reduced beta-muricholic acid levels, overview
-
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
the enzyme is necessary for the synthesis of cholic acid
-
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
additional information
?
-
-
bile acids repress human CYP8B1 transcription by reducing the transactivation activity of HNF4alpha through interaction of HNF4alpha with SHP and reduction of HNF4alpha expression in the liver
-
-
?
additional information
?
-
-
IL-1beta inhibits CYP8B1 gene transcription via a mitogen-activated protein kinase/c-Jun NH2-terminal kinase pathway that inhibits HNF4alpha gene expression and its DNA-binding ability. This mechanism may play an important role in the adaptive response to inflammatory cytokines and the protection of the liver during cholestasis
-
-
?
additional information
?
-
-
variation in the ratio between cholic acid and chenodeoxycholic acid in human bile are not due to polymorphisms in gene CYP8B1, overview
-
-
?
additional information
?
-
-
CYP8B1 is reportedly regulated by PPARalpha, overview
-
-
?
additional information
?
-
-
the enzyme expression is not affected by primary biliary cirrhosis
-
-
?
additional information
?
-
-
the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview
-
-
?
additional information
?
-
-
HNF4alpha directly binds to the promoter region of the mouse cyp8b1 and positively regulates its expression. CYP8B1 enzyme activity is absent in HNF4alphaDELTAL mice
-
-
?
additional information
?
-
-
sterol regulatory element binding proteins 1a and 1c enhance transcription of the CYP8B1 gene through binding to sterol regulatory element. Cholesterol loading reduces sterol regulatory element binding proteins 1 mRNA expression in addition to reducing functional sterol regulatory element binding proteins 1 protein, and results in decreasing CYP8B1 gene transcription
-
-
?
additional information
?
-
-
CYP8B1 is reportedly regulated by PPARalpha, overview
-
-
?
additional information
?
-
-
the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview
-
-
?
additional information
?
-
-
while Cyp8b1 repression by the nuclear bile acid receptor FXR is also intact in mice deficient for liver receptor homolog 1, LRH-1, in hepatocytes, basal CYP8B1 mRNA levels are significantly decreased and there are corresponding changes in the composition of the bile acid pool. Liver receptor homolog 1, LRH-1, is either not involved in the feedback regulation of bile acid synthesis or is compensated for by other factors
-
-
?
additional information
?
-
-
the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview
-
-
?
additional information
?
-
-
key enzyme of the bile acid biosynthetic pathway. It regulates the composition of bile acids in bile, i.e. ratio between cholic acid and chenodeoxycholic acid. Bile acids inhibit CYP8B1 gene transcription by inducing alpha-fetoprotein transcription factor and inhibiting HNF4alpha expression
-
-
?
additional information
?
-
-
specific enzyme required for cholic acid synthesis. The levels of this enzyme determine the ratio of cholic acid to chenodeoxycholic acid and thus the hydrophobicity of the circulating bile acid pool
-
-
?
additional information
?
-
-
sterol regulatory element binding proteins 1a and 1c enhance transcription of the CYP8B1 gene through binding to sterol regulatory element. Cholesterol loading reduces sterol regulatory element binding proteins 1 mRNA expression in addition to reducing functional sterol regulatory element binding proteins 1 protein, and results in decreasing CYP8B1 gene transcription
-
-
?
additional information
?
-
-
the enzyme is involved in bile acid synthesis, critical importance for the composition of bile acids formed in the liver, regulated by thyroid hormone at the mRNA level
-
-
?
additional information
?
-
-
the enzyme is required for biosynthesis of cholic acid. CYP8b1 is transcriptionally down-regulated by hydrophobic but not hydrophilic bile acids. Cholesterol feeding and a single thyroid hormone injection repress CYP8b1 in face of cholesterol 7alpha-hydroxylase specific activities
-
-
?
additional information
?
-
-
the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview
-
-
?
additional information
?
-
-
key enzyme in cholic acid biosynthesis
-
-
?
additional information
?
-
-
the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2
7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
additional information
?
-
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
activation of farnesoid X receptor FXR initiates a feedback regulatory loop via induction of small heterodimer partner, SHP, which suppresses liver receptor homolog 1, LRH-1, and HNF4alpha dependent expression of sterol 12alpha hydroxylase, CYP8B1, overview
-
-
?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
the enzyme is involved in bile acid synthesis, repression of bile acid synthesis and induction of basolateral bile acid export may represent adaptive mechanisms to limit bile acid burden in chronic cholestasis, but the changes do not sufficiently counteract cholestatic liver damage, overview
-
-
?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
a key step in bile acid synthesis
-
-
?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2
7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
-
microsomal enzyme activity was markedly elevated by starvation or streptozotocin administration to the animals
-
-
?
7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2
7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
-
key enzyme for the formation of cholic acid
-
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
thyroid hormone triiodothyronine has a regulatory function on the enzyme expressiona and bile acid metabolism, overview
-
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
dietary cholsterol and cholic acid have an influence of enzyme regulation
-
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
the enzyme channels bile acid precursors into cholic acid, but is not affected on mRNA and protein levels by increased cholic acid or reduced beta-muricholic acid levels, overview
-
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
the enzyme is necessary for the synthesis of cholic acid
-
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
additional information
?
-
-
bile acids repress human CYP8B1 transcription by reducing the transactivation activity of HNF4alpha through interaction of HNF4alpha with SHP and reduction of HNF4alpha expression in the liver
-
-
?
additional information
?
-
-
IL-1beta inhibits CYP8B1 gene transcription via a mitogen-activated protein kinase/c-Jun NH2-terminal kinase pathway that inhibits HNF4alpha gene expression and its DNA-binding ability. This mechanism may play an important role in the adaptive response to inflammatory cytokines and the protection of the liver during cholestasis
-
-
?
additional information
?
-
-
variation in the ratio between cholic acid and chenodeoxycholic acid in human bile are not due to polymorphisms in gene CYP8B1, overview
-
-
?
additional information
?
-
-
CYP8B1 is reportedly regulated by PPARalpha, overview
-
-
?
additional information
?
-
-
the enzyme expression is not affected by primary biliary cirrhosis
-
-
?
additional information
?
-
-
the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview
-
-
?
additional information
?
-
-
HNF4alpha directly binds to the promoter region of the mouse cyp8b1 and positively regulates its expression. CYP8B1 enzyme activity is absent in HNF4alphaDELTAL mice
-
-
?
additional information
?
-
-
sterol regulatory element binding proteins 1a and 1c enhance transcription of the CYP8B1 gene through binding to sterol regulatory element. Cholesterol loading reduces sterol regulatory element binding proteins 1 mRNA expression in addition to reducing functional sterol regulatory element binding proteins 1 protein, and results in decreasing CYP8B1 gene transcription
-
-
?
additional information
?
-
-
CYP8B1 is reportedly regulated by PPARalpha, overview
-
-
?
additional information
?
-
-
the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview
-
-
?
additional information
?
-
-
while Cyp8b1 repression by the nuclear bile acid receptor FXR is also intact in mice deficient for liver receptor homolog 1, LRH-1, in hepatocytes, basal CYP8B1 mRNA levels are significantly decreased and there are corresponding changes in the composition of the bile acid pool. Liver receptor homolog 1, LRH-1, is either not involved in the feedback regulation of bile acid synthesis or is compensated for by other factors
-
-
?
additional information
?
-
-
the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview
-
-
?
additional information
?
-
-
key enzyme of the bile acid biosynthetic pathway. It regulates the composition of bile acids in bile, i.e. ratio between cholic acid and chenodeoxycholic acid. Bile acids inhibit CYP8B1 gene transcription by inducing alpha-fetoprotein transcription factor and inhibiting HNF4alpha expression
-
-
?
additional information
?
-
-
specific enzyme required for cholic acid synthesis. The levels of this enzyme determine the ratio of cholic acid to chenodeoxycholic acid and thus the hydrophobicity of the circulating bile acid pool
-
-
?
additional information
?
-
-
sterol regulatory element binding proteins 1a and 1c enhance transcription of the CYP8B1 gene through binding to sterol regulatory element. Cholesterol loading reduces sterol regulatory element binding proteins 1 mRNA expression in addition to reducing functional sterol regulatory element binding proteins 1 protein, and results in decreasing CYP8B1 gene transcription
-
-
?
additional information
?
-
-
the enzyme is involved in bile acid synthesis, critical importance for the composition of bile acids formed in the liver, regulated by thyroid hormone at the mRNA level
-
-
?
additional information
?
-
-
the enzyme is required for biosynthesis of cholic acid. CYP8b1 is transcriptionally down-regulated by hydrophobic but not hydrophilic bile acids. Cholesterol feeding and a single thyroid hormone injection repress CYP8b1 in face of cholesterol 7alpha-hydroxylase specific activities
-
-
?
additional information
?
-
-
the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview
-
-
?
additional information
?
-
-
key enzyme in cholic acid biosynthesis
-
-
?
additional information
?
-
-
the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase deficiency
Bile acid composition regulates GPR119-dependent intestinal lipid sensing and food intake regulation in mice.
Carcinoma, Hepatocellular
Disruption of Stard10 gene alters the PPAR?-mediated bile acid homeostasis.
Cholelithiasis
Reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone.
Cholelithiasis
Single nucleotide polymorphism rs3732860 in the 3'-untranslated region of CYP8B1 gene is associated with gallstone disease in Han Chinese.
Cholestasis
Effects of microplastics (MPs) and tributyltin (TBT) alone and in combination on bile acids and gut microbiota crosstalk in mice.
Cholestasis, Intrahepatic
Differential effects of 17alpha-ethinylestradiol on the neutral and acidic pathways of bile salt synthesis in the rat.
cholesterol 7alpha-monooxygenase deficiency
Impact of physiological levels of chenodeoxycholic acid supplementation on intestinal and hepatic bile acid and cholesterol metabolism in Cyp7a1-deficient mice.
Colorectal Neoplasms
Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.
Coronary Thrombosis
New anti-platelet agents: the end of resistance?
Diabetes Mellitus, Type 2
Rethinking Bile Acid Metabolism and Signaling for Type 2 Diabetes Treatment.
Dyslipidemias
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Dyslipidemias
Sterol 12?-hydroxylase Aggravates Dyslipidemia by Activating the Ceramide/mTORC1/SREBP1C Pathway via FGF21 and FGF15.
Fatty Liver
Genetic ablation of Cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition.
Fatty Liver
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Gallstones
[Association of single nucleotide polymorphism in human CYP8B1 gene with gallstone disease].
Hyperglycemia
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Hypertension
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Hypertension
Whole rat DNA array survey for candidate genes related to hypertension in kidneys from three spontaneously hypertensive rat substrains at two stages of age and with hypotensive induction caused by hydralazine hydrochloride.
Infections
Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo.
Infections
Reciprocal regulation of farnesoid X receptor ? activity and hepatitis B virus replication in differentiated HepaRG cells and primary human hepatocytes.
Insulin Resistance
Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1.
Insulin Resistance
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Insulin Resistance
Sterol 12?-hydroxylase Aggravates Dyslipidemia by Activating the Ceramide/mTORC1/SREBP1C Pathway via FGF21 and FGF15.
Liver Cirrhosis
Chemical profile of Swertia mussotii Franch and its potential targets against liver fibrosis revealed by cross-platform metabolomics.
Liver Diseases
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Liver Diseases
Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice.
Liver Diseases
Toxicogenomics directory of chemically exposed human hepatocytes.
Liver Failure
Thyroid hormone suppresses hepatic sterol 12alpha-hydroxylase (CYP8B1) activity and messenger ribonucleic acid in rat liver: failure to define known thyroid hormone response elements in the gene.
Metabolic Diseases
Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice.
Metabolic Syndrome
STUDIES ON THE EXPRESSION LEVELS OF STEROL-METABOLIZING ENZYMES IN THE OBESE MODEL SHR/NDmcr-cp RATS.
Non-alcoholic Fatty Liver Disease
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice.
Obesity
Chemical synthesis of 7-oxygenated 12?-hydroxy steroid derivatives to enable the biochemical characterization of cytochrome P450 8B1, the oxysterol 12?-hydroxylase enzyme implicated in cardiovascular health and obesity.
Obesity
Chemical synthesis of 7?-hydroxycholest-4-en-3-one, a biomarker for irritable bowel syndrome and bile acid malabsorption.
Obesity
Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
Starvation
Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns.
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Jahan, A.; Chiang, J.Y.
Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene
Am. J. Physiol.
288
G685-695
2005
Homo sapiens
brenda
Yang, Y.; Eggertsen, G.; Gafvels, M.; Andersson, U.; Einarsson, C.; Bjorkhem, I.; Chiang, J.Y.
Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1)
Biochem. Biophys. Res. Commun.
320
1204-1210
2004
Mus musculus, Rattus norvegicus
brenda
Andersson, U.; Eggertsen, G.; Bjorkhem, I.
Rabbit liver contains one major sterol 12alpha-hydroxylase with broad substrate specificity
Biochim. Biophys. Acta
1389
150-154
1998
Oryctolagus cuniculus
brenda
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Rattus norvegicus
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Homo sapiens
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Homo sapiens, Mus musculus
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Homo sapiens
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Mus musculus
brenda
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Homo sapiens
brenda
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Rattus norvegicus
brenda
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Rattus norvegicus
brenda
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Mus musculus
brenda