Reference on EC 1.14.19.17 - sphingolipid 4-desaturase
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Beauchamp, E.; Goenaga, D.; Le Bloch, J.; Catheline, D.; Legrand, P.; Rioux, V.
Myristic acid increases the activity of dihydroceramide DELTA4-desaturase 1 through its N-terminal myristoylation
Biochimie
89
1553-1561
2007
Rattus norvegicus (Q5XIF5)
Beauchamp, E.; Tekpli, X.; Marteil, G.; Lagadic-Gossmann, D.; Legrand, P.; Rioux, V.
N-myristoylation targets dihydroceramide DELTA4-desaturase 1 to mitochondria: Partial involvement in the apoptotic effect of myristic acid
Biochimie
91
1411-1419
2009
Rattus norvegicus (Q564G3)
Garton, S.; Michaelson, L.V.; Beaudoin, F.; Beale, M.H.; Napier, J.A.
The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe
FEBS Lett.
538
192-196
2003
Schizosaccharomyces pombe (O59715), Schizosaccharomyces pombe
Michel, C.; Van Echten-Deckert, G.; Rother, J.; Sandhoff, K.; Wang, E.; Merrill Jr., A.
Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide
J. Biol. Chem.
272
22432-22437
1997
Rattus norvegicus (Q564G3)
Ternes, P.; Franke, S.; Zaehringer, U.; Sperling, P.; Heinz, E.
Identification and characterization of a sphingolipid delta 4-desaturase family
J. Biol. Chem.
277
25512-25518
2002
Caenorhabditis elegans (G5EC63), Mus musculus (O09005), Mus musculus, Homo sapiens (O15121), Homo sapiens, Candida albicans (Q5AJX2), Candida albicans, Drosophila melanogaster (Q94515), Drosophila melanogaster
Ternes, P.; Wobbe, T.; Schwarz, M.; Albrecht, S.; Feussner, K.; Riezman, I.; Cregg, J.; Heinz, E.; Riezman, H.; Feussner, I.; Warnecke, D.
Two pathways of sphingolipid biosynthesis are separated in the yeast Pichia pastoris
J. Biol. Chem.
286
11401-11414
2011
Komagataella pastoris
Causeret, C.; Geeraert, L.; Van der Hoeven, G.; Mannaerts, G.; Van Veldhoven, P.
Further characterization of rat dihydroceramide desaturase: Tissue distribution, subcellular localization, and substrate specificity
Lipids
35
1117-1125
2000
Rattus norvegicus (Q564G3)
Ezanno, H.; Le Bloch, J.; Beauchamp, E.; Lagadic-Gossmann, D.; Legrand, P.; Rioux, V.
Myristic acid increases dihydroceramide DELTA4-desaturase 1 (DES1) activity in cultured rat hepatocytes
Lipids
47
117-128
2012
Rattus norvegicus (Q564G3)
Beckmann, C.; Rattke, J.; Sperling, P.; Heinz, E.; Boland, W.
Stereochemistry of a bifunctional dihydroceramide DELTA4-desaturase/hydroxylase from Candida albicans; a key enzyme of sphingolipid metabolism
Org. Biomol. Chem.
1
2448-2454
2003
Candida albicans
Luttgeharm, K.; Kimberlin, A.; Cahoon, R.; Cerny, R.; Napier, J.; Markham, J.; Cahoon, E.
Sphingolipid metabolism is strikingly different between pollen and leaf in Arabidopsis as revealed by compositional and gene expression profiling
Phytochemistry
115
121-129
2015
Arabidopsis thaliana
Zhu, Q.; Yang, J.; Zhu, R.; Jiang, X.; Li, W.; He, S.; Jin, J.
Dihydroceramide-desaturase-1-mediated caspase 9 activation through ceramide plays a pivotal role in palmitic acid-induced HepG2 cell apoptosis
Apoptosis
21
1033-1044
2016
Homo sapiens
Rodriguez-Cuenca, S.; Barbarroja, N.; Vidal-Puig, A.
Dihydroceramide desaturase 1, the gatekeeper of ceramide induced lipotoxicity
Biochim. Biophys. Acta
1851
40-50
2015
Chlorocebus aethiops, Mus musculus (O09005), Homo sapiens (O15121), Drosophila melanogaster (Q94515)
Casasampere, M.; Ordonez, Y.F.; Casas, J.; Fabrias, G.
Dihydroceramide desaturase inhibitors induce autophagy via dihydroceramide-dependent and independent mechanisms
Biochim. Biophys. Acta
1861
264-275
2017
Homo sapiens
Pou, A.; Abad, J.L.; Ordonez, Y.F.; Garrido, M.; Casas, J.; Fabrias, G.; Delgado, A.
From the configurational preference of dihydroceramide desaturase-1 towards DELTA6-unsaturated substrates to the discovery of a new inhibitor
Chem. Commun. (Camb.)
53
4394-4397
2017
Homo sapiens
Casasampere, M.; Ordonez, Y.F.; Pou, A.; Casas, J.
Inhibitors of dihydroceramide desaturase 1 Therapeutic agents and pharmacological tools to decipher the role of dihydroceramides in cell biology
Chem. Phys. Lipids
197
33-44
2016
Drosophila melanogaster, Drosophila melanogaster (Q94515), Mus musculus (O09005), Homo sapiens (O15121), Rattus norvegicus (Q5XIF5)
Cingolani, F.; Casasampere, M.; Sanllehi, P.; Casas, J.; Bujons, J.; Fabrias, G.
Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II
J. Lipid Res.
55
1711-1720
2014
Homo sapiens
Aurelio, L.; Scullino, C.V.; Pitman, M.R.; Sexton, A.; Oliver, V.; Davies, L.; Rebello, R.J.; Furic, L.; Creek, D.J.; Pitson, S.M.; Flynn, B.L.
From sphingosine kinase to dihydroceramide desaturase a structure-activity relationship (SAR) study of the enzyme inhibitory and anticancer activity of 4-((4-(4-chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)
J. Med. Chem.
59
965-984
2016
Homo sapiens
Jang, Y.; Rao, X.; Jiang, Q.
Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment
J. Nutr. Biochem.
46
49-56
2017
Homo sapiens (O15121)
McNaughton, M.; Pitman, M.; Pitson, S.M.; Pyne, N.J.; Pyne, S.
Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells
Oncotarget
7
16663-16675
2016
Homo sapiens
Poliakov, E.; Samuel, W.; Duncan, T.; Gutierrez, D.B.; Mata, N.L.; Redmond, T.M.
Inhibitory effects of fenretinide metabolites N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR) on fenretinide molecular targets beta-carotene oxygenase 1, stearoyl-CoA desaturase 1 and dihydroceramide DELTA4-desaturase 1
PLoS ONE
12
e0176487
2017
Mus musculus (O09005), Homo sapiens (O15121), Mus musculus C57BL/6 (O09005)
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