2.4.1.B64: glucosyltransferase Waag

This is an abbreviated version!
For detailed information about glucosyltransferase Waag, go to the full flat file.

Reaction

alpha-L-glycero-D-manno-heptosyl-(1->3)-alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

alpha-D-glucosyl-(1->3)-alpha-L-glycero-D-manno-heptosyl-(1->3)-alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

Synonyms

(heptosyl)2-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A:UDP-alpha-D-glucose glucosyltransferase, core glucosyltransferase, glycosyltransferase WaaG, lipopolysaccharide core biosynthesis protein, lipopolysaccharide glucosyltransferase I, LPS glucosyltransferase I, RfaG, UDP-glucose:(heptosyl) lipopolysaccharide alpha-1,3-glucosyltransferase, WaaG

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.B64 glucosyltransferase Waag

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Results	in table
4	Activating Compound
2	AA Sequence
2	Application
4	Cloned(Commentary)
2	Crystallization (Commentary)
7	General Information
1	IC50 Value
4	Inhibitors
2	KM Value [mM]
1	Localization
1	Metals/Ions
2	Natural Substrates/ Products (Substrates)
10	Organism
3	Protein Variants
3	Purification (Commentary)
1	Reaction
10	Reference
5	Substrates and Products (Substrate)
17	Synonyms
1	Systematic Name
2	Turnover Number [1/s]

Localization

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Localization on EC 2.4.1.B64 - glucosyltransferase Waag

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membrane

Escherichia coli

P25740

WaaG is membrane-bound, membrane association mechanism, overview. Binding of WaaG to membranes is analyzed by stopped-flow fluorescence and NMR diffusion experiments. Electrostatic interactions are required to bind WaaG to membranes while mere hydrophobic interactions are not sufficient. WaaG senses the membrane's surface charge density but there is no preferential binding to specific anionic lipids. The binding is weaker than expected for monotopic GTs but similar to peripheral GTs. Therefore, WaaG may be a peripheral GT and this can be of functional relevance in vivo since LPS synthesis occurs only when WaaG is membrane-bound. No C-terminal domain movement is observed under the experimental conditions

16020

758841