2.4.1.90: N-acetyllactosamine synthase

This is an abbreviated version!
For detailed information about N-acetyllactosamine synthase, go to the full flat file.

Word Map on EC 2.4.1.90

2.4.1.90

oligosaccharide

glycosyltransferases

galactosylation

n-glycans

alpha-lactalbumin

ganglioside

glycosphingolipids

zona

pellucida

glucosylceramide

laccer

zp3

sperm-egg

d-pdmp

ga2

poly-n-acetyllactosamine

udp-galnac

medicine

synthesis

biotechnology

Reaction

Synonyms

acetyllactosamine synthetase, B4GALT1, B4GALT3, B4GalT5, beta 1,4 galactosyltransferase I, beta 1,4-galactosyltransferase 1, beta 1,4GalT II, beta 1,4GTI, beta(1,4)-galactosyltransferase, beta(1,4)-GT, beta(1-4)galactosyltransferase, beta-1,4-galactosyltransferase, beta-1,4-galactosyltransferase 1, beta-1,4-galactosyltransferase III, beta-1,4-galactosyltransferase IV, beta-1,4-galactosyltransferase-1, beta-1,4-galactosyltransferase-I, beta-1,4-galactosyltransferase-V, beta-1,4-GalT, beta-1,4-GalT-I, beta-1,4-GalT-V, beta-1,4-GT-IV, beta-1,4-N-acetylgalactosaminyltransferase, beta-N-acetylglucosaminide beta1-4-galactosyltransferase, beta1,4-Gal-transferase T1, beta1,4-galactosyltransferase, beta1,4-galactosyltransferase I, beta1,4-galactosyltransferase II, beta1,4-galactosyltransferase V, beta1,4-galactosyltransferase-1, beta1,4-galactosyltransferase-7, beta1,4-galactosyltransferase-I, beta1,4-GT, beta1,4GalT II, beta1,4GalTV, beta1-4-galactosyltransferase, beta1-4GalT, beta4Gal-T, beta4Gal-T1, beta4Gal-T7, beta4GalT, beta4GalT1, betaGALT1, beta[1-4]GalT, EC 2.4.1.98, Gal-T, galactosyltransferase, uridine diphosphogalactose-acetylglucosamine, GalNAcT, GALT, GalT1, GalT7, GalTase, GalTase-I, GTase, Hp1-4GalT, lactosamine synthase, lactosamine synthetase, lactose synthetase A protein, lactosylceramide synthase, More, N-acetyllactosamine synthetase, NAL synthetase, NmLgtB, UDP-beta-1,4-galactosyltransferase, UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 5, UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase, UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase, UDP-galactose-acetylglucosamine galactosyltransferase, UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase, UDP-galactose-N-acetylglucosamine galactosyltransferase, UDP-galactose/N-acetylglucosamine beta1,4 galactosyltransferase, UDP-galactose: N-acetylglucosamine beta 1-4 galactosyltransferase, UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase, UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase, UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase, uridine diphosphogalactose-acetylglucosamine galactosyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.90 N-acetyllactosamine synthase

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Results	in table
36	Activating Compound
42	AA Sequence
10	Application
1	CAS Registry Number
31	Cloned(Commentary)
11	Crystallization (Commentary)
305	Disease/ Diagnostics
3	Expression
6	General Information
4	General Stability
15	IC50 Value
72	Inhibitors
2	Ki Value [mM]
85	KM Value [mM]
84	Localization
78	Metals/Ions
22	Molecular Weight [Da]
45	Natural Substrates/ Products (Substrates)
109	Organism
69	PDB ID
28	pH Optimum
2	pH Range
1	pH Stability
2	pI Value
8	Posttranslational Modification
42	Protein Variants
29	Purification (Commentary)
8	Reaction
1	Reaction Type
109	Reference
1	Renatured (Commentary)
125	Source Tissue
38	Specific Activity [micromol/min/mg]
13	Storage Stability
218	Substrates and Products (Substrate)
23	Subunits
109	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
5	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 2.4.1.90 - N-acetyllactosamine synthase

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106000

Homo sapiens

calculation from light-scattering experiments

38000

x * 38000, SDS-PAGE

42200

x * 42200, SDS-PAGE

42960

calculation from gene sequence, short form, transmembrane enzyme

43000

x * 43000, SDS-PAGE

440000

gel filtration

44420

long form with NH2-terminal extension of 13 amino acids, calculation from gene sequence

489498

44880

Bos taurus

unglycosylated enzyme, calculation from gene sequence

489505

47000

Homo sapiens

x * 47000, deglycosylated enzyme form, SDS-PAGE

489508

48000

Homo sapiens

x * 48000, glycosylated enzyme form

51000

x * 51000, SDS-PAGE

53000

x * 53000, SDS-PAGE

54000

x * 54000, enzyme from milk, SDS-PAGE

55000

2 * 55000, SDS-PAGE

57000

sucrose density gradient centrifugation

489531

59000

Bos taurus

gel filtration

489466

66000

Trichosurus vulpecula

x * 66000, SDS-PAGE

70000

gel filtration

72600

gel filtration

74000

1 * 74000, SDS-PAGE

85000 - 90000

gel filtration

additional information

Mus musculus

two related forms of enzyme of 399 and 386 amino acids are synthesized as a consequence of alternative translation initiation. The long enzyme form has a NH2-terminal extension of 13 amino acids

489498