2.4.1.88: globoside alpha-N-acetylgalactosaminyltransferase

This is an abbreviated version!
For detailed information about globoside alpha-N-acetylgalactosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-globoside alpha-, cis-AB-transferase, Forss-S, Forssman synthase, Forssman synthetase, Forssmann glycolipid synthetase, FS, GBGT1, globoside acetylgalactosaminyltransferase, globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, glycosyltransferase 6 (GT6) family member, GT6m5, GT6m6, GT6m7, histo-blood group ABO system transferase, More, uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.88 globoside alpha-N-acetylgalactosaminyltransferase

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Results	in table
15	Activating Compound
9	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
1	Crystallization (Commentary)
10	Disease/ Diagnostics
2	Expression
4	General Information
4	General Stability
34	Inhibitors
1	Ki Value [mM]
6	KM Value [mM]
8	Localization
16	Metals/Ions
7	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
19	Organism
3	Pathway
6	pH Optimum
1	pH Range
2	Protein Variants
2	Purification (Commentary)
2	Reaction
1	Reaction Type
16	Reference
24	Source Tissue
5	Specific Activity [micromol/min/mg]
3	Storage Stability
24	Substrates and Products (Substrate)
2	Subunits
30	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 2.4.1.88 - globoside alpha-N-acetylgalactosaminyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

UDP-N-acetyl-alpha-D-galactosamine + globoside

UDP + N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

2 entries

UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-D-galactosaminyl-(1->3)-D-galactosyl-(1->4)-D-galactosyl-(1->4)-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-(1->3)-N-acetyl-D-galactosaminyl-(1->3)-D-galactosyl-(1->4)-D-galactosyl-(1->4)-D-glucosylceramide

Homo sapiens

Q8N5D6

-

735858

-

-

?

UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

10 entries

UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R

UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R

2 entries

UDP-N-acetyl-D-galactosamine + N-acetylgalactosaminyl-1,3-beta-galactosyl-alpha-1,3-galactosyl-beta-1,4-glucosylceramide

UDP + N-acetyl-D-galactosamine-1,3-N-acetylgalactosaminyl-1,3-beta-galactosyl-alpha-1,3-galactosyl-beta-1,4-glucosylceramide

Canis lupus familiaris

-

-

489481

-

-

?

UDP-N-acetyl-D-galactosamine + oligosaccharide of globoside

?

Canis lupus familiaris

-

-

489481

-

-

?

additional information

?

-

8 entries

UDP-N-acetyl-alpha-D-galactosamine + globoside

UDP + N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

Canis lupus familiaris

-

-

489481, 489482

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + globoside

UDP + N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

Cavia porcellus

-

-

489480

-

-

?

UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

Canis lupus familiaris

-

-

489481

i.e. Forssman hapten

489481

?

UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

Canis lupus familiaris

-

-

489482

i.e. Forssman hapten

489482

?

UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

Canis lupus familiaris

Q95158

i.e. globoside, catalyzes the transfer of N-acetylgalactosamine in alpha-1,3-linkage to globoside

489484

-

-

?

UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

Canis lupus familiaris

-

i.e. globoside, catalyzes the transfer of N-acetylgalactosamine in alpha-1,3-linkage to globoside

489481

i.e. Forssman hapten

489481

ir

UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

Canis lupus familiaris

-

general structure of preferred substrates: N-acetylgalactosaminyl-beta-1,3-galactosyl-O-R

489481

i.e. Forssman hapten

489481

ir

UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

Canis lupus familiaris

-

involved in biosynthesis of carbohydrate moiety of sphingoglycolipids

489482

i.e. Forssman hapten

489482

?

UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

Cavia porcellus

-

-

489480

i.e. Forssman hapten

489480

?

UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

Cavia porcellus

-

-

489483

i.e. Forssman hapten

489483

?

UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

Homo sapiens

O75752

-

489386

i.e. Forssman antigen

489386

?

UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

Homo sapiens

Q8N5D6

no activity

489485

-

-

?

UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R

UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R

Canis lupus familiaris

Q95158

production of the Forssman antigen

658838

-

-

?

UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R

UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R

Canis lupus familiaris

Q95158

substrate binding mechanism, binding site structures and involved amino acids, binding of the nucleotide sugar requires the residues A263, D206, E297, Q296, W295, and S180, binding of the acceptor sugar involves residues H228, Y259, E298, and others, overview

658838

-

-

?

additional information

?

-

Canis lupus familiaris

-

no substrates: oligosaccharide of blood type H substance, asialo-GM1, asialo-GM2 and GD1a, galactosyl-alpha-1,4-galactosyl-beta-1,4-glucosylceramide, UDP, UDP-galactose, 2'-fucosyllactose, H blood group glycoprotein, bovine submaxillary deglycosylated mucin, GM1-3, glucosyl-beta-1,1-ceramide, galactosyl-beta-1,1-ceramide, galactosyl-beta-1,4-glucosylceramide

489481

-

-

?

additional information

?

-

Canis lupus familiaris

-

enzyme is responsible for production of Forssman glycolipid, the enzyme modifies the Shiga toxin receptor glycolipids, e.g. globotriaosylceramide, to Forssman glycolipid, which results in highly decreased susceptibility for Shiga toxin, the enzyme expression level is directly related to the level of sensitivity for the cytotoxin

658898

-

-

?

additional information

?

-

Homo sapiens

-

variability in glycolipid synthesis between species is an important determinant of microbial tropism

489485

-

-

?

additional information

?

-

Homo sapiens

Q8N5D6

variability in glycolipid synthesis between species is an important determinant of microbial tropism

489485

-

-

?

additional information

?

-

Homo sapiens

Q8N5D6

synthesis of Forssman (Fs) antigen, a pentaglycosyl ceramide (GalNAcalpha1-3GalNAcbeta1-3Galalpha1-4Galbeta1-4Glcbeta1-1Cer) terminated by GalNAc and belongs to the globo series of glycosphingolipids

735858

-

-

?

additional information

?

-

Homo sapiens

-

synthesis of Forssman (Fs) antigen, a pentaglycosyl ceramide (GalNAcalpha1-3GalNAcbeta1-3Galalpha1-4Galbeta1-4Glcbeta1-1Cer) terminated by GalNAc and belongs to the globo series of glycosphingolipids

735858

-

-

?

additional information

?

-

Mus musculus

-

enzyme is responsible for production of Forssman glycolipid, the enzyme modifies the Shiga toxin receptor glycolipids, e.g. globotriaosylceramide, to Forssman glycolipid, which results in highly decreased susceptibility for Shiga toxin, the enzyme expression level is directly related to the level of sensitivity for the cytotoxin

658898

-

-

?

additional information

?

-

Mus musculus

P38649

mouse ABO gene-encoded cis-AB transferase, EC 2.4.1.37/2.4.1.40, contains the GlyGlyAla tripeptide sequence, which is also found in the majority of GBGT1 genes encoding Forssman glycolipid synthase. Mouse cis-AB transferase with the GlyGlyAla tripeptide sequence, but not the human cis-AB transferase with the LeuGlyAla, exhibits Forssman glycolipid synthase activity equivalent of mouse GBGT1 gene-encoded Forssman glycolipid synthase

758408

-

-

-