2.4.1.68: glycoprotein 6-alpha-L-fucosyltransferase This is an abbreviated version! For detailed information about glycoprotein 6-alpha-L-fucosyltransferase, go to the full flat file .
Word Map on EC 2.4.1.68
Reaction
GDP-beta-L-fucose +
N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein] =
GDP +
N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc]-L-asparaginyl-[protein]
Synonyms 6FucT, alfC, alpha(1,6)FT, alpha(1,6)fucosyltransferase, alpha-1,6-fucosyltransferase, alpha-6-fucosyltransferase, alpha1,6-fucosyltransferase, alpha1,6-FucT, alpha1,6FucT, alpha1-6,fucosyltransferase, alpha1-6FucT, alpha6FucT, BN194_28780, fucosyltransferase 8, fucosyltransferase, guanosine diphosphofucose-glycoprotein, FUT8, GDP-fucose glycoprotein fucosyltransferase, GDP-fucose-glycoprotein fucosyltransferase, GDP-L-fuc:N-acetyl-beta-D-glucosaminide alpha1-6fucosyltransferase, GDP-L-fucose-glycoprotein fucosyltransferase, GDP-L-fucose:2-acetamido-2-deoxy-beta-D-glucoside 6-alpha-L-fucosyltransferase, GDPfucose glycoprotein fucosyltransferase, glycoprotein fucosyltransferase, guanosine diphosphofucose-glycoprotein fucosyltransferase, NodZ, NodZ fucosyltransferase
ECTree
Source Tissue
Source Tissue on EC 2.4.1.68 - glycoprotein 6-alpha-L-fucosyltransferase
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14 splice variants of the alpha6-fucosyltransferase gene are expressed early in human embryos
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CD34+ cell, activity of 6FucT increases ahead of, and thereafter concomitantly with, cells expressing the CD41a antigen. When the CD41a+ subpopulation of cells is immunoselected (using anti-CD61 i.e. anti GpIIIa antibodies), its 6FucT activity increases proportionally to the yield of DC61+ cells
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heavy load of 6FucT
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thrombin-activated neutrophils release cathepsin G and elastase during coagulation of blood, which promotes the degranulation of platelets and hence the secretion of alpha-6-fucosyltransferase
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thrombin-activated neutrophils release cathepsin G and elastase during coagulation of blood, which promotes the degranulation of platelets and hence the secretion of alpha-6-fucosyltransferase
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heavy load of 6FucT
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a significant increase in the alpha(1,6)FT expression in colorectal tumour tissues as compared to healthy and transitional tissues, inflammatory lesions and adenomas is observed
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kidney
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expression in hepatoma tissues and their surrounding tissues and in tissues with chronic disease, overview
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DAB-induced hepatoma
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expression in hepatoma tissues and their surrounding tissues and in tissues with chronic disease, overview
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enzyme is expressed in hepatoma tissues and their surrounding tissues with chronic disease, but not in normal liver
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fetal and adult
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