2.4.1.244: N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase

This is an abbreviated version!
For detailed information about N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase, go to the full flat file.

Reaction

Synonyms

B4GALNT3, beta 1,4-N-acetylgalactosaminyltransferase-A, beta1,4-N-acetylgalactosaminyltransferase, beta1,4-N-acetylgalactosaminyltransferase II, beta1,4-N-acetylgalactosaminyltransferase III, beta1,4-N-acetylgalactosaminyltransferase IV, beta1,4-N-acetylgalactosaminyltransferase-III, beta4GalNAc-T3, beta4GalNAc-T4, beta4GalNAcT, beta4GalNAcT-II, beta4GalNAcTA, beta4GalNAcTB, N,N'-diacetyllactosediamine synthase, N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1, N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.244 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase

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Results	in table
1	Activating Compound
1624	AA Sequence
1	Application
2	CAS Registry Number
9	Cloned(Commentary)
39	Disease/ Diagnostics
1	Expression
2	General Information
1	Inhibitors
3	Localization
5	Natural Substrates/ Products (Substrates)
13	Organism
2	Pathway
1	Protein Variants
3	Purification (Commentary)
1	Reaction
12	Reference
23	Source Tissue
37	Substrates and Products (Substrate)
24	Synonyms
1	Systematic Name

Natural Substrates Products

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Natural Substrates Products on EC 2.4.1.244 - N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl-R group

UDP + N-acetyl-beta-D-galactosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl-R group

2 entries

additional information

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6 entries

UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl-R group

UDP + N-acetyl-beta-D-galactosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl-R group

Drosophila sp. (in: flies)

-

beta4Gal-NAcTA has at least three distinct, tissue-specific roles in neurons and muscles. Substrates are present in both neural and muscle cells that require glycosylation by beta4GalNAcTA for normal function

673868

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-

?

UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl-R group

UDP + N-acetyl-beta-D-galactosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl-R group

Drosophila sp. (in: flies)

-

beta4GalNAcTA contributs to the synthesis of the GalNAcbeta1,4GlcNA structure in vivo and may play a role in the physiological or neuronal development of Drosophila

671792

-

-

?

additional information

?

-

Drosophila melanogaster

-

flies mutant for beta4GalNAcTA are viable and fertile but display behavioral phenotypes suggestive of essential roles for GalNAc-beta1,4-GlcNAc containing glycoconjugates in neuronal and/or muscular function

658854

-

-

?

additional information

?

-

Drosophila melanogaster

Q7KN92

flies mutant for beta4GalNAcTA are viable and fertile but display behavioral phenotypes suggestive of essential roles for GalNAc-beta1,4-GlcNAc containing glycoconjugates in neuronal and/or muscular function

658854

-

-

?

additional information

?

-

Drosophila melanogaster

-

flies mutant for beta4GalNAcTB are viable and display no evident morphological or behavioral phenotypes

658854

-

-

?

additional information

?

-

Drosophila melanogaster

Q7KN92

flies mutant for beta4GalNAcTB are viable and display no evident morphological or behavioral phenotypes

658854

-

-

?

additional information

?

-

Homo sapiens

Q6L9W6

the enzyme could transfer GalNAc residues, producing N,N'-diacetylgalactosediamine structures at least in N-glycans and probably in both N- and O-glycans

669203

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme could transfer GalNAc residues, producing N,N'-diacetylgalactosediamine structures at least in N-glycans and probably in both N- and O-glycans

669203

-

-

?