2.4.1.225: N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase

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For detailed information about N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase, go to the full flat file.

Reaction

Synonyms

diphosphoglucuronate:oligosaccharide uridine glucuronosyltransferase, exostosin, exostosin-1, exostosin-2, Exostosin1, Exostosin2, exotose-2, EXT-1, EXT-2, EXT-3, EXT1, EXT2, EXTL3, extosin, gene EXTL1 glycosyltransferase, gene EXTL2 glycosyltransferase, glucuronic acid/N-acetylglucosamine co-polymerase-1, glucuronosyltransferase, heparan glucuronosyltransferase II, heparan sulfate co-polymerase, heparan sulfate glucuronosyltransferase, heparan sulfate synthesis enzyme, N-acetylglucosaminylproteoglycan beta-1,4-glucuronosyltransferase, RIB-1, RIB-2, sister of tout velu, sister of tout-velu, sotv, tout velu, tout-velu, ttv, UDP-glucuronate:oligosaccharide

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.225 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase

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Results	in table
245	AA Sequence
2	Application
1	CAS Registry Number
12	Cloned(Commentary)
183	Disease/ Diagnostics
4	Expression
30	General Information
1	General Stability
18	Localization
4	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
106	Organism
3	Pathway
10	PDB ID
3	pI Value
4	Posttranslational Modification
20	Protein Variants
2	Purification (Commentary)
1	Reaction
40	Reference
37	Source Tissue
3	Specific Activity [micromol/min/mg]
22	Substrates and Products (Substrate)
6	Subunits
72	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.4.1.225 - N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase

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SYSTEMATIC NAME

IUBMB Comments

UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase

Involved in the biosynthesis of heparin and heparan sulfate. Some forms of the human enzyme (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase (EC 2.4.1.224) activity required for the synthesis of the heparan sulfate disaccharide repeats.