This is an abbreviated version! For detailed information about 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase, go to the full flat file.
suppression of isoform Fut10 expression induces the differentiation of neural stem cells and embryonic stem cells. In addition, knockdown of Fut10 expression in the cortical ventricular zone of the embryonic brain impairs the radial migration of neural precursor cells
glycoproteins from tobacco line xFxG1, in which expression of a hybrid beta-(1-4)-galactosyltransferase and a hybrid a-(1-3)-fucosyltransferase IXa (FUT9a) is combined, contain an abundance of hybrid N-glycans with Lewis X (LeX) epitopes
protein kinase R is the primary target for Herpes simplex virus type 1 early RNA during induction of FUT3, FUT5, and FUT6, whereby the subsequent steps in the transcriptional activation of these host genes involve a hitherto unknown IMD-0354, yet IKK-2-independent, pathway
synthesis of E- and P-selectin ligands, as mediated by the rate-limiting enzyme FucT-VII, plays an important role in the pathogenesis of atherosclerosis
upregulation of selectin ligands in the endometrium at the time of implantation may be mediated, at least in part, by the regulation of FUT4 expression
overexpression of FUT6 in hepatocellular carcinoma cells enhance S-phase cell population, promoted cell growth and colony formation ability. FUT6 plays an important role in hepatocellular carcinoma cell growth by regulating the phosphatidyl inositol 3-kinase/Akt signaling pathway
fucosyltransferase IV is implicated in the modulation of cell migration, invasion and cancer metastasis. The enzyme has a role in epithelial-mesenchymal transition through activation of the phosphatidylinositol 3-kinase/Akt and nuclear factor-kappaB signaling systems, which induce the key mediators Snail and MMP-9 and facilitate the acquisition of a mesenchymal phenotype
following FUT7 siRNA transfection, the expression of FUT7 is markedly downregulated. The synthesis of sialyl-Lewisx epitope is also inhibited, consistent with the downregulated expression of FUT7. MHCC-97 cell proliferation is also significantly inhibited following FUT7 siRNA transfection, which is correlated with suppression of the S-phase in cell cycle progression. The knockdown of FUT7 inhibits the activation of phospholipase Cgamma by inhibiting its translocation and phosphorylation
FUT7 overexpression significantly promotes monocyte-endothelial adhesion, while FUT7 knockdown inhibits IL-1beta-induced monocyte-endothelial adhesion. Fucosylation of selectin ligand endomucin is directly involved in IL-1beta-induced monocyte-endothelial adhesion. p38 and extracellular signal-regulated kinase (ERK) MAPK signaling pathway are activated by IL-1beta, while inhibition of the p38/ERK signaling pathway decreases FUT7 expression level and IL-1beta-induced monocyte-endothelial adhesion
knocking-out of two XylT genes and four FucT genes in BY-2 suspension cells using CRISPR/Cas9. Three lines show a strong reduction of beta(1,2)-xylose and alpha(1,3)-fucose, while two lines are completely devoid of them, indicating complete gene inactivation. The KO lines do not show any particular morphology and grow as the wild-type. A KO line transformed with genes encoding a human IgG2 antibody shows an IgG2 expression level as high as in a control transformant. The IgG glycosylation profile shows no beta(1,2)-xylose or alpha(1,3)-fucose present on the glycosylation moiety. The dominant glycoform is the GnGn structure
proteins derived from the alpha1,3-fucosyltransferase LORE1 insertion mutant completely lack alpha1,3-core fucosylation. The Lotus japonicus convicilin 2 is one of the main glycoproteins undergoing differential expression/N-glycosylation in the mutant. Reduced growth and seed production phenotypes are observed for the mutant plants, even though the relative protein composition and abundance appear unaffected