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2.4.1.150: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.150

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+
beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-R
=
UDP
 +
beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R

Synonyms

2beta-1,6-acetylglucosaminyltransferase, acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-acetyllactosaminide beta1-->6-, beta1-6GnT, C2/4GnT, C24GNT, C2GnT, C2GnT2, C2GNTM, core 2 beta-1,6-N-acetylglucosaminyltransferase, core 2beta-1,6-acetylglucosaminyltransferase, dIHnT, distally acting I-branching beta1,6-N-acetylglucosaminyltransferase, EC 2.4.1.164, Galbeta1-->4GlcNAc-R beta1-->6 N-acetylglucosaminyltransferase, GCNT2, Gcnt2 gene product, gcnt3, glucosaminyl (N-acetyl) transferase 2, GNTM, I beta1,6-N-acetylglucosaminyltransferase, I N-acetylglucosaminyltransferase, I-branching beta-1,6-N-acetylglucosaminyl transferase 2, I-branching beta-1,6-N-acetylglucosaminyltransferase, I-branching enzyme, I-branching N-acetylglucosaminyltransferase, IGnT, More, N-acetylglucosaminyltransferase, N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase, UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminide 6-beta-N-acetyl-D-glucosaminyltransferase, uridine diphosphoacetylglucosamine-acetyllactosaminide beta1-->6-acetylglucosaminyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.150 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase

Expression

Expression on EC 2.4.1.150 - N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
GCNT3 downregulation by shGCNT3 7, of several shRNAs targeting GCNT3 shGCNT3s, shGCNT3 7 has the best inhibitory capacity (protein and mRNA)
-
in mouse pancreatic cancer tumors, GCNT3 upregulation (103fold) is correlated with increased expression of mucins (5 to 87fold). Pancreata from 6-week-old Kras mice treated with talniflumate for 1 week show a significant decrease in GCNT3 and mucin expression in PanIN lesions. Further, GCNT3 protein expression is significantly decreased in the pancreas of talniflumate-treated Kras mice compared with untreated control mouse pancreas. mRNA expression of GCNT3 is also observed to be lower in pancreatic tissues from talniflumate-treated mice
modulation of GCNT3 expression in the presence of 5-fluorouracil (5FU) at 0.03 mM, a robust induction of GCNT3 expression is observed in SW family of non-resistant cells with a statistically significant 3.76fold increase in SW620 metastatic cells, while no such induction is observed in SW5FU cells or in HT-29 cell line, which has the highest levels of endogenous GCNT3
-
talniflumate alone and in combination with low-dose gefitinib reduces GCNT3 expression, leading to the disrupted production of mucins in vivo and in vitro, in silico molecular docking studies. Talniflumate binds to GCNT3 with a docking affinity of -8.3 kcal/mol and deeper in the pocket of GCNT3. GALB1,3GALNAC's best docking affinity is -7.51 kcal/mol, achieved closer to the surface of GCNT3