2.4.1.148: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

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For detailed information about acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta(1-->6)-, B, bC2GnT-M, C2GnT, C2GnT-2, C2GnT-I, C2GnT-L, c2GnT-M, C2GnT1, C2GnT2, C2GnT3, core 2 beta 1,6 N-acetylglucosaminyltransferase, core 2 beta-1,6-N-acetylglucosaminyltransferase, core 2 beta-1,6-N-acetylglucosaminyltransferase-M, core 2 beta1,6-N-acetylglucosaminyltransferase, core 2 beta6 GlcNAc-transferase, core 2 N-acetylglucosaminyltransferase-M, core 2 _1,6 N-acetylglucosaminyltransferase mucus-type, core 4 beta6-GalNAc-transferase, core 6beta-GalNAc-transferase B, leukocyte-type core 2 beta1,6-N-acetylglucosaminyltransferase, More, mucin-type core 2 beta-1,6-N-acetylglucosaminyltransferase-M, mucin-type core 2 beta-6-GlcNAc-transferase, O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV, uridine diphosphoacetylglucosamine-mucin beta(1-->6)-acetylglucosaminyltransferase B

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.148 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

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Results	in table
7	Activating Compound
13	AA Sequence
1	Application
2	CAS Registry Number
4	Cloned(Commentary)
2	Cofactor
1	Crystallization (Commentary)
3	Disease/ Diagnostics
3	General Information
10	Inhibitors
2	Ki Value [mM]
4	KM Value [mM]
6	Localization
4	Metals/Ions
2	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
23	Organism
3	Pathway
5	pH Optimum
1	Posttranslational Modification
5	Protein Variants
2	Purification (Commentary)
2	Reaction
1	Reaction Type
23	Reference
38	Source Tissue
10	Specific Activity [micromol/min/mg]
88	Substrates and Products (Substrate)
2	Subunits
44	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]

Cloned

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Cloned on EC 2.4.1.148 - acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

functional expression in CHO cells, soluble chimeric enzyme form shows core 4 6beta-GalNAc transferase activity, DNA and amino acid sequence determination

Bovine gammaherpesvirus 4

Q9IZK2

638289

mutant enzyme C217S is expressed in HEK-293T cells

Mus musculus

-

722983

phylogenetic analysis, the gene Bo17, encoding the enzyme, is acquired from an ancestor of the African buffalo 1.5 million years ago

Bovine gammaherpesvirus 4

-

662559

stable expression of the enzyme, lacking the cytoplasmic tail and the transmembrane domain, in CHO cells, secretion of the fully active recombinant enzyme to the culture medium

Bos taurus

-

659384