2.3.1.39: [acyl-carrier-protein] S-malonyltransferase

This is an abbreviated version!
For detailed information about [acyl-carrier-protein] S-malonyltransferase, go to the full flat file.

Word Map on EC 2.3.1.39

2.3.1.39

fas

carboxylase

sterol

triglyceride

lipogenesis

acetyl-coa

adipose

lipogenic

peroxisome

cholesterol

obesity

proliferator-activated

adipocytes

element-binding

lipoprotein

carnitine

lipase

high-fat

steatosis

hepatocytes

srebp-1c

stearoyl-coa

obese

diet-induced

protein-1c

triacylglycerols

palmitate

amp-activated

leptin

anti-obesity

cerulenin

preadipocytes

nafld

adiponectin

palmitoylation

nonalcoholic

malic

lipolysis

hormone-sensitive

srebps

desaturase-1

hfd-induced

orlistat

enoyl

atp-citrate

acyl-acps

acaca

medicine

diagnostics

drug development

palmitoyltransferase-1

biotechnology

chrebp

anti-adipogenic

synthesis

Reaction

Synonyms

EtMCAT, FabD, FabD2, FAS, fatty acid synthase, HpMCAT, malonyl CoA-ACP malonyltransferase, malonyl CoA-ACP transacylase, malonyl CoA-acyl carrier protein transacylase, malonyl coenzyme A-acyl carrier protein transacylase, malonyl coenzyme A:acyl carrier protein transacylase, malonyl transacylase, malonyl transferase, malonyl-CoA acyl carrier protein transacylase, malonyl-CoA-acyl carrier protein transacylase, malonyl-CoA/ACP transacylase, malonyl-CoA/holo-ACP transacylase, malonyl-CoA: ACP transacylase, malonyl-CoA:ACP transacylase, malonyl-CoA:AcpM transacylase, malonyl-CoA:acyl carrier protein transacylase, malonyl-CoA:acyl-carrier protein transacylase, malonyl-CoA�acyl carrier protein transacylase, malonyl-coenzyme A (CoA)/holo-ACP transacylase, malonyl-coenzyme A-holo-acyl-carrier protein transacylase, malonyl-coenzyme A: acyl-carrier protein transacylase, malonyl-coenzyme A:ACP transacylase, malonyl-coenzymeA:acyl-carrier protein transacylase, malonyltransferase, [acyl-carrier-protein], MAT, MCAMT, MCAT, MCT, MdcH, More, mtFabD, SaMCAT, SpnMCAT, XoMCAT, [acyl carrier protein]malonyltransferase

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.39 [acyl-carrier-protein] S-malonyltransferase

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Results	in table
3	Activating Compound
39861	AA Sequence
5	Application
1	CAS Registry Number
37	Cloned(Commentary)
13	Crystallization (Commentary)
4263	Disease/ Diagnostics
4	Expression
20	General Information
8	General Stability
1	IC50 Value
59	Inhibitors
5	kcat/KM [mM/s]
6	Ki Value [mM]
78	KM Value [mM]
13	Localization
34	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
111	Organism
11	Pathway
94	PDB ID
26	pH Optimum
3	pH Range
1	pH Stability
1	pI Value
1	Posttranslational Modification
52	Protein Variants
31	Purification (Commentary)
15	Reaction
1	Reaction Type
85	Reference
2	Renatured (Commentary)
20	Source Tissue
46	Specific Activity [micromol/min/mg]
6	Storage Stability
122	Substrates and Products (Substrate)
13	Subunits
102	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
11	Temperature Stability [°C]
35	Turnover Number [1/s]

KM Value

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KM Value on EC 2.3.1.39 - [acyl-carrier-protein] S-malonyltransferase

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0.11

acetoacetyl-CoA

Escherichia coli

mutant enzyme R117A, pH and temperature not specified in the publication

755871

0.2

acetyl-CoA

Escherichia coli

mutant enzyme R117A, pH and temperature not specified in the publication

755871

0.042 - 1.3

acyl-carrier protein

8 entries

0.011 - 0.04

an [acyl-carrier protein]

6 entries

0.0141

holo-acyl-carrier protein

Mycobacterium tuberculosis

holo-acyl-carrier protein from Mycobacterium tuberculosis

486892

0.0094 - 0.015

malonyl CoA

2 entries

0.0013 - 1.4

malonyl-CoA

43 entries

0.016 - 0.58

methylmalonyl-CoA

4 entries

0.00134

pantetheine

Persea americana

285678

0.075 - 3.5

[acyl-carrier protein]

10 entries

additional information

Streptomyces coelicolor

the Km for N-acetylcysteamine is significantly higher than for an acyl-carrier-protein

486893