2.3.1.261: (4-hydroxyphenyl)alkanoate synthase

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For detailed information about (4-hydroxyphenyl)alkanoate synthase, go to the full flat file.

Word Map on EC 2.3.1.261

2.3.1.261

polyketide

ketosynthase

at-less

spoligotyping

trans-at

ketoreductase

phenolphthiocerol

phthiocerol

leinamycin

diagnostics

euro-american

indo-oceanic

dimycocerosate

nrps-pk

Reaction

4-hydroxybenzoyl-[(4-hydroxyphenyl)alkanoate synthase]

+ 8 malonyl-CoA + 16 NADPH + 16 H+ =

17-(4-hydroxyphenyl)heptadecanoyl-[(4-hydroxyphenyl)alkanoate synthase]

+ 8 CO2 + 8 CoA + 16 NADP⁺ + 8 H2O

Synonyms

4-hydroxyphenylalkanoate synthase, msl7, PKS1, Pks15, Pks15/1, type I PKS

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.261 (4-hydroxyphenyl)alkanoate synthase

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Results	in table
4	AA Sequence
2	Application
2	Cloned(Commentary)
12	General Information
2	Natural Substrates/ Products (Substrates)
202	Organism
1	Pathway
2	Protein Variants
2	Reaction
11	Reference
4	Substrates and Products (Substrate)
24	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.3.1.261 - (4-hydroxyphenyl)alkanoate synthase

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malonyl-CoA:4-hydroxybenzoyl-[(4-hydroxyphenyl)alkanoate synthase] malonyltransferase [(4-hydroxyphenyl)alkanoate-forming]

The enzyme is part of the biosynthetic pathway of phenolphthiocerol, a lipid that serves as a virulence factor of pathogenic mycobacteria. It catalyses the elongation of 4-hydroxybenzoate that is loaded on its acyl-carrier domain to form (4-hydroxyphenyl)alkanoate intermediates. The enzyme adds either 8 or 9 malonyl-CoA units, resulting in formation of 17-(4-hydroxyphenyl)heptadecanoate or 19-(4-hydroxyphenyl)nonadecanoate, respectively. As the enzyme lacks a thioesterase domain [1], the product remains loaded on the acyl-carrier domain at the end of catalysis, and has to be hydrolysed by an as-yet unknown mechanism.