2.3.1.241: Kdo2-lipid IVA acyltransferase

This is an abbreviated version!
For detailed information about Kdo2-lipid IVA acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.241

2.3.1.241

neisseria

meningitidis

meningococcal

lipopolysaccharide

bactericidal

penta-acylated

nomvs

hexa-acylated

endotoxic

serogrouping

poras

lipooligosaccharide

reactogenicity

monophosphoryl

underacylated

detergent-treated

2'-position

tetra-acylated

drug development

Reaction

(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

Synonyms

(Kdo)2-lipid IVA lauroyltransferase, alpha-Kdo-(2->4)-alpha-(2->6)-lipid IVA lauroyltransferase, dodecanoyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA O-dodecanoyltransferase, dodecanoyl-[acyl-carrier protein]:Kdo2-lipid IVA O-dodecanoyltransferase, ESA02293, htrB, HtrB1, Kdo2-lipid IVA lauroyltransferase, lauroyl-[acyl-carrier protein]:Kdo2-lipid IVA O-lauroyltransferase, lipid A biosynthesis lauroyltransferase, LpxL, LpxL1, LpxL2, lpxL_1, lpxL_2, PA0011, PP_1735

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.241 Kdo2-lipid IVA acyltransferase

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Results	in table
2	Activating Compound
7114	AA Sequence
1	Application
5	Cloned(Commentary)
1	Expression
6	General Information
1	General Stability
2	Inhibitors
2	KM Value [mM]
1	Localization
1	Metals/Ions
2	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
13	Organism
12	Pathway
2	pH Optimum
5	Protein Variants
2	Purification (Commentary)
1	Reaction
10	Reference
2	Specific Activity [micromol/min/mg]
14	Substrates and Products (Substrate)
1	Subunits
27	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.3.1.241 - Kdo2-lipid IVA acyltransferase

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fatty acyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[lipid IVA] O-acyltransferase

The enzyme is involved in the biosynthesis of the phosphorylated outer membrane glycolipid lipid A. It transfers an acyl group to the 3-O position of the 3R-hydroxyacyl already attached to the nitrogen of the non-reducing glucosamine molecule. The enzyme from the bacterium Escherichia coli is specific for lauryl (C12) acyl groups, giving the enzyme its previous accepted name. However, enzymes from different species accept highly variable substrates.