2.1.4.1: glycine amidinotransferase
This is an abbreviated version!
For detailed information about glycine amidinotransferase, go to the full flat file.
Word Map on EC 2.1.4.1
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2.1.4.1
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creatine
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guanidinoacetate
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homoarginine
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slc6a8
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harg
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phosphocreatine
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medicine
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creatine-deficient
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transamidination
- 2.1.4.1
- creatine
- guanidinoacetate
- homoarginine
-
slc6a8
- harg
- phosphocreatine
- medicine
-
creatine-deficient
-
transamidination
Reaction
Synonyms
AGAT, arginine-glycine amidinotransferase, arginine-glycine transamidinase, arginine:glycine amidinotransferase, CyrA, EC 2.6.2.1, GAT, GATM, glycine amidinotransferase, glycine aminotransferase, glycine transamidinase, L-arginine:glycine amidinotransferase
ECTree
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Temperature Stability
Temperature Stability on EC 2.1.4.1 - glycine amidinotransferase
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44.5
an inactivated form of this enzyme retains an appreciable amount of secondary structure elements even on heating to 94°C, but loses its tertiary structure at low temperature of 44.5°C resulting in a state reminiscent of a molten globule. The presence of 500 mm NaCl decreases Tmax at pH 7.5 from 54°C to 49°C
additional information
inactive CyrA lacks a well-defined tertiary structure at any temperature
additional information
the three mutant variants have lower Tmax values than the wild-type with 54°C compared to 48°C, 51.5°C and 49.5°C for F245N, S247M, and F245N/S247M, respectively