2.1.2.3: phosphoribosylaminoimidazolecarboxamide formyltransferase

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For detailed information about phosphoribosylaminoimidazolecarboxamide formyltransferase, go to the full flat file.

Word Map on EC 2.1.2.3

2.1.2.3

amp-activated

methotrexate

glycinamide

folate-dependent

antifolate

medicine

polyglutamates

faicar

garftase

folylpolyglutamate

pyrrolo2,3-dpyrimidines

10-formyldihydrofolate

garft

drug development

diagnostics

Reaction

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

Synonyms

10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase, 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase, 5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase, 5-amino-4-imidazolecarboxamide ribonucleotide transformylase, 5-amino-4-imidazolecarboxamide ribotide formyltransferase, 5-amino-4-imidazolecarboxamide ribotide transformylase, 5-aminoimidazole-4-carboxamide ribonucleotide, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide tranformylase, 5-aminoimidazole-4-carboxamide ribonucleotide tranformylase/IMP cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (AICAR Tfase)-inosine monophosphate cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide-transformylase, 5-aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase, 5-aminoimidazole-4-carboxamideribonucleotide formyltransferase, AICA ribonucleotide formyltransferase, AICA-ribotide formyltransferase, AICAR formyltransferase, AICAR TFase, AICAR tranformylase, AICAR tranformylase/IMP cyclohydrolase, AICAR transformylase, AICAR transformylase/IMP cyclohydrolase, AICAR transformylase/inosine monophosphate cyclohydrolase, AICAR-transformylase, AICAR-transformylase/IMP cyclohydrolase, AICARFT, AICARFT/IMPCHase, AICARFTase, AICARTfase, AIRCARFTase, aminoimidazole-4-carboxamide ribonucleotide formyltransferase, aminoimidazole-4-carboxamide ribonucleotide transformylase, aminoimidazolecarboxamide ribonucleotide transformylase, aminoimidazolecarboxamide ribotide transformylase, ATIC, atic-1, Bifunctional purine biosynthesis protein, C55F2.1, IMPCH, PurH, TM1249, ZMP formyltransferase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.2 Hydroxymethyl-, formyl- and related transferases

2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase

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Results	in table
1	Activating Compound
38517	AA Sequence
25	Application
1	CAS Registry Number
23	Cloned(Commentary)
26	Cofactor
14	Crystallization (Commentary)
117	Disease/ Diagnostics
2	Expression
29	General Information
1	General Stability
52	IC50 Value
186	Inhibitors
3	kcat/KM [mM/s]
24	Ki Value [mM]
46	KM Value [mM]
8	Localization
4	Metals/Ions
9	Molecular Weight [Da]
84	Natural Substrates/ Products (Substrates)
277	Organism
8	Pathway
46	PDB ID
4	pH Optimum
4	pH Range
4	pH Stability
1	pI Value
1	Posttranslational Modification
9	Protein Variants
28	Purification (Commentary)
2	Reaction
3	Reaction Type
83	Reference
73	Source Tissue
7	Specific Activity [micromol/min/mg]
1	Storage Stability
216	Substrates and Products (Substrate)
21	Subunits
120	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Temperature Range [°C]
5	Temperature Stability [°C]
6	Turnover Number [1/s]

KM Value

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KM Value on EC 2.1.2.3 - phosphoribosylaminoimidazolecarboxamide formyltransferase

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0.0602

(6R,6S)-10-formyltetrahydrofolic acid

Homo sapiens

P31939

172163

0.245

10-formyldihydrofolate

Escherichia coli

P15639

pH 7.5, temperature not specified in the publication

757625

0.00051

10-formyldihydrofolic acid pentaglutamate

Gallus sp.

485749

0.0043 - 0.2

10-formyltetrahydrofolate

9 entries

0.031

5'-phosphoribosyl-5-amino-imidazolecarboxamide

Pisum sativum

485745

0.01 - 0.3243

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

8 entries

0.0009

5-amino-imidazole-4-thiocarboxamide ribonucleotide

Homo sapiens

10-formyldihydrofolate as cofactor

485756

0.0005 - 0.0168

5-aminoimidazole-4-carboxamide ribonucleotide

7 entries

0.0021

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

Staphylococcus lugdunensis

A0A133Q8U5

at pH 7.4, temperature not specified in the publication

756701

0.00183 - 0.00313

N10-formyltetrahydropteroylheptaglutamate

2 entries

0.00164 - 0.00195

N10-formyltetrahydropteroylhexaglutamate

2 entries

0.00165 - 0.353

N10-formyltetrahydropteroylmonoglutamate

2 entries

0.00206 - 0.00256

N10-formyltetrahydropteroylpentaglutamate

2 entries

0.00099 - 0.00107

N10-formyltetrahydropteroyltetraglutamate

2 entries

0.00595 - 0.674

N10-formyltetrahydropteroyltriglutamate

2 entries

0.185

tetrahydrofolate

Homo sapiens

485759

0.00023

tetrahydrofolic acid

Gallus sp.

485749

additional information

2 entries