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2.1.1.B140: tRNAHis-specific 5'-phosphate monomethyltransferase

This is an abbreviated version!
For detailed information about tRNAHis-specific 5'-phosphate monomethyltransferase, go to the full flat file.

Word Map on EC 2.1.1.B140

Reaction

a 5'-(5'-phospho)-tRNAHis
+
S-adenosyl-L-methionine
=
a 5'-(5'-phosphomethyl)-tRNAHis
 +
S-adenosyl-L-homocysteine

Synonyms

BCDIN3D, tRNAHis-specific 5'-monomethylphosphate capping enzyme

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.B140 tRNAHis-specific 5'-phosphate monomethyltransferase

Engineering

Engineering on EC 2.1.1.B140 - tRNAHis-specific 5'-phosphate monomethyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D110A
the mutant shows severely reduced activity compared to the wild type enzyme
D135A
the mutant shows severely reduced activity compared to the wild type enzyme
D72A
the mutant shows severely reduced activity compared to the wild type enzyme
D72A/G74A
the mutant shows severely reduced activity compared to the wild type enzyme
F136G
the mutant shows severely reduced activity compared to the wild type enzyme
F40A
inactive
G74A
the mutant shows severely reduced activity compared to the wild type enzyme
I111G
the mutant shows severely reduced activity compared to the wild type enzyme
I166G
the mutant shows severely reduced activity compared to the wild type enzyme
K201A
the mutant shows severely reduced activity compared to the wild type enzyme
N76A
the mutant shows severely reduced activity compared to the wild type enzyme
Q198A
the mutant shows severely reduced activity compared to the wild type enzyme
R118A
the mutant shows reduced activity compared to the wild type enzyme
R204A
the mutant shows severely reduced activity compared to the wild type enzyme
R208A
the mutant shows severely reduced activity compared to the wild type enzyme
R208A/R209A
the mutant shows severely reduced activity compared to the wild type enzyme
R211A
the mutant shows severely reduced activity compared to the wild type enzyme
R211A/R212A
inactive
R212A
the mutant shows severely reduced activity compared to the wild type enzyme
R257A
the mutant shows severely reduced activity compared to the wild type enzyme
R46A
the mutant shows severely reduced activity compared to the wild type enzyme
S165A
the mutant shows severely reduced activity compared to the wild type enzyme
W169F
the mutant shows severely reduced activity compared to the wild type enzyme
Y37A
the mutant shows severely reduced activity compared to the wild type enzyme
Y37F
inactive