2.1.1.59: [cytochrome c]-lysine N-methyltransferase
This is an abbreviated version!
For detailed information about [cytochrome c]-lysine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.59
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2.1.1.59
-
unmethylated
-
neurospora
-
horse
-
iso-1-cytochrome
-
apocytochrome
-
14cmethyl
-
s-transferase
-
crassa
-
epsilon-n-trimethyllysine
-
trimethylated
- 2.1.1.59
-
unmethylated
- neurospora
- horse
-
iso-1-cytochrome
-
apocytochrome
-
14cmethyl
- s-transferase
- crassa
-
epsilon-n-trimethyllysine
-
trimethylated
Reaction
Synonyms
cytochrome c (lysine) methyltransferase, cytochrome c methyltransferase, cytochrome c-specific protein methylase III, cytochrome c-specific protein-lysine methyltransferase, methyltransferase, cytochrome c (lysine)
ECTree
2.1.1.59 [cytochrome c]-lysine N-methyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.1.1.59 - [cytochrome c]-lysine N-methyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
S-adenosyl-L-methionine + myoglobin L-lysine
S-adenosyl-L-homocysteine + myoglobin N6-methyl-L-lysine
-
10% activity compared to cytochrome c
-
?
S-adenosyl-L-methionine + [apocytochrome c]-L-lysine
S-adenosyl-L-homocysteine + [apocytochrome c]-N6-methyl-L-lysine
-
-
-
-
r
S-adenosyl-L-methionine + [cytochrome c]-L-lysine
S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
a single lysine residue at position 72 of horse heart cytochrome c is methylated
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
a single lysine residue at position 72 of horse heart cytochrome c is methylated
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
important features in determining methyl-accepting activity: 1. reactive site such as-X-Lys-Lys-Y-, 2. length of polypeptide chain, 3. tertiary structure
a single lysine residue at position 72 of horse heart cytochrome c is methylated, mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
does not randomly methylate cytochrome c, but shows absolute specificity for some amino acid sequences
a single lysine residue at position 72 of horse heart cytochrome c is methylated
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
does not randomly methylate cytochrome c, but shows absolute specificity for some amino acid sequences
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
does not randomly methylate cytochrome c, but shows absolute specificity for some amino acid sequences
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
also CNBr peptides of horse heart cytochrome c can serve as substrates, overview
a single lysine residue at position 72 of horse heart cytochrome c is methylated
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
also CNBr peptides of horse heart cytochrome c can serve as substrates, overview
a single lysine residue at position 72 of horse heart cytochrome c is methylated
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
also CNBr peptides of horse heart cytochrome c can serve as substrates, overview
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
also CNBr peptides of horse heart cytochrome c can serve as substrates, overview
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
overview: substrate activity of various cytochromes c
a single lysine residue at position 72 of horse heart cytochrome c is methylated, mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
specific for unmethylated cytochrome c
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
specific for unmethylated cytochrome c
a single lysine residue at position 72 of horse heart cytochrome c is methylated, 9:17:74, mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
recombinant substrate iso-1-apocytochrome c
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
a single lysine residue at position 72 of horse heart cytochrome c is methylated, 9:17:74, mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
trimethylation of recombinant iso-1-cytochrome c of lysine at position 72
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
overview: substrate activity of various cytochromes c
a single lysine residue at position 72 of horse heart cytochrome c is methylated, 9:17:74, mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
in vivo methylation of cytochrome c in yeast occurs probably before cytochrome c is attached to the mitochondria
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
regulation of enzyme and cytochrome c substrate is not in parallel manner
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
lysine-72 of horse cytochrome c is a poor acceptor
uptake of methyl groups occurs only at lysine residue 8 and the terminal proline residue
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
Crithidia cytochrome c-557 is far the best substrate
uptake of methyl groups occurs only at lysine residue 8 and the terminal proline residue
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
-
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
avian cytochromes c are much better substrates than those from mammalian sources
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
horse heart cytochrome c-72
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
does not randomly methylate cytochrome c, but shows absolute specificity for some amino acid sequences
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
also CNBr peptides of horse heart cytochrome c can serve as substrates, overview
-
?
S-adenosyl-L-methionine + cytochrome c L-lysine
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
overview: substrate activity of various cytochromes c
-
?
S-adenosyl-L-methionine + [cytochrome c]-L-lysine
S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine
-
-
-
-
r
S-adenosyl-L-methionine + [cytochrome c]-L-lysine
S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine
-
-
-
-
r
