2.1.1.281: phenylpyruvate C3-methyltransferase
This is an abbreviated version!
For detailed information about phenylpyruvate C3-methyltransferase, go to the full flat file.
Reaction
Synonyms
C-MT, ELQ87_35210, MppJ, MT SgvM, phenylpyruvate Cbeta-methyltransferase, phenylpyruvate methyltransferase, S-adenosylmethionine-dependent methyltransferase, SgvM
ECTree
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Application
Application on EC 2.1.1.281 - phenylpyruvate C3-methyltransferase
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synthesis
the nonenzymatic stereoselective formation of C-C bonds by methylation is challenging and usually requires multistep syntheses. In contrast, the asymmetric introduction of a methyl group in natural product biosynthesis is performed in a single step and catalyzed by methyltransferases (MTs), which usually require S-adenosylmethionine (SAM) as the methyl donor. Enzyme SgvM might be a valuable tool for asymmetric biocatalytic C-alkylation reactions. It catalyze the transfer of the electrophilic methyl group of SAM to the C3 position