2.1.1.226: 23S rRNA (cytidine1920-2'-O)-methyltransferase
This is an abbreviated version!
For detailed information about 23S rRNA (cytidine1920-2'-O)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.226
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2.1.1.226
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aminoglycosides
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amikacin
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carbapenemase
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extended-spectrum
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plasmid-mediated
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esbls
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carbapenem-resistant
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aminoglycoside-modifying
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methylase-producing
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blactx-m
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aac6\'-ib
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aac6\'-ib-cr
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blatem
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blactx-m-15
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aminoglycoside-resistant
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arbekacin
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blakpc-2
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macrolide-lincosamide-streptogramin
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ndm-1-producing
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carbapenemase-producing
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amikacin-resistant
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carbapenemase-encoding
- 2.1.1.226
- aminoglycosides
- amikacin
- carbapenemase
-
extended-spectrum
-
plasmid-mediated
-
esbls
-
carbapenem-resistant
-
aminoglycoside-modifying
-
methylase-producing
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blactx-m
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aac6\'-ib
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aac6\'-ib-cr
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blatem
- blactx-m-15
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aminoglycoside-resistant
- arbekacin
- blakpc-2
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macrolide-lincosamide-streptogramin
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ndm-1-producing
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carbapenemase-producing
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amikacin-resistant
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carbapenemase-encoding
Reaction
Synonyms
2'-O-methyltransferase, Cj0588, More, rRNA 2'-O-methyltransferase, rRNA methylase, rRNA methylase TlyA, TlyA, TlyAI, TlyAII
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.226 - 23S rRNA (cytidine1920-2'-O)-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
S-adenosyl-L-methionine + cytidine1920 in 50S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
the 50S subunit is the preferred substrate, a modest amount of methylation is seen with free 23S rRNA and 70S ribosomes
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S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
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S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
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S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
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S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
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S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
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S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
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S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
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the bifunctional enzyme modifies nucleotide C1409 in helix 44 of 16S rRNA and nucleotide C1920 in helix 69 of 23S rRNA
the exact position of the methyl group in the wild-type rRNAs is verified by MALDI quadrupole-TOF tandem MS analysis
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S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
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S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
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S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
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S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
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S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
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S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
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the 50S subunit is the preferred substrate, a modest amount of methylation is seen with free 23S rRNA and 70S ribosomes
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?
S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 23S rRNA
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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the 50S subunit is the preferred substrate, a modest amount of methylation is seen with free 23S rRNA and 70S ribosomes
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S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
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S-adenosyl-L-methionine + cytidine1920 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
the 50S subunit is the preferred substrate, a modest amount of methylation is seen with free 23S rRNA and 70S ribosomes
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?
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
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S-adenosyl-L-methionine + cytidine1920 in 50S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
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S-adenosyl-L-methionine + cytidine1920 in 50S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1920 in 50S rRNA
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50S rRNA is used as substrate in activity assays. Mass spectrometric analyses of Campylobacter jejuni 23S rRNA
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additional information
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50S rRNA is used as substrate in activity assays. Mass spectrometric analyses of Campylobacter jejuni 23S rRNA
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additional information
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50S rRNA is used as substrate in activity assays. Mass spectrometric analyses of Campylobacter jejuni 23S rRNA
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additional information
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the 2'-O-methyltransferase TlyA from Mycobacterium tuberculosis methylates both nucleotide C1409 of 16S rRNA, EC 2.1.1.227, and C1920 of 23S rRNA
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additional information
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the purified recombinant enzyme TlyA efficiently 2'-O-methylates C1920 in vitro at a molar enzyme to substrate ratio of 1:10
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additional information
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the bifunctional enzyme exhibits the activities of EC 2.1.1.226 and EC 2.1.1.227
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additional information
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the bifunctional enzyme exhibits the activities of EC 2.1.1.226 and EC 2.1.1.227
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additional information
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the 2'-O-methyltransferase TlyA from Mycobacterium tuberculosis methylates both nucleotide C1409 of 16S rRNA, EC 2.1.1.227, and C1920 of 23S rRNA
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additional information
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the purified recombinant enzyme TlyA efficiently 2'-O-methylates C1920 in vitro at a molar enzyme to substrate ratio of 1:10
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additional information
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the TlyAII enzyme methylates efficiently at C1920 in 50S subunits in vitro, although weaker activity is also detected on 70S ribosome and 23S rRNA substrates
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additional information
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the TlyAII enzyme methylates efficiently at C1920 in 50S subunits in vitro, although weaker activity is also detected on 70S ribosome and 23S rRNA substrates
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