1.5.8.4: dimethylglycine dehydrogenase
This is an abbreviated version!
For detailed information about dimethylglycine dehydrogenase, go to the full flat file.
Word Map on EC 1.5.8.4
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1.5.8.4
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sarcosine
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fad
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flavinylated
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folate-binding
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wagner
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medicine
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diagnostics
- 1.5.8.4
- sarcosine
- fad
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flavinylated
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folate-binding
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wagner
- medicine
- diagnostics
Reaction
Synonyms
Csal_0990, DdhC, DMGDH, EC 1.5.99.2, Me2GlyDH, mMe2GlyDH, N,N-dimethylglycine oxidase, pMe2GlyDH
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General Information
General Information on EC 1.5.8.4 - dimethylglycine dehydrogenase
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malfunction
rare natural mutation H109R, causes dimethylglycine dehydrogenase deficiency leading to increased blood and urinary dimethylglycine concentrations
metabolism
physiological function
the enzyme takes part in choline degradation, one-carbon metabolism and electron transfer to the respiratory chain
metabolism
the phosphorylation of Akt-308/473 is significantly suppressed when the enzyme is overexpressed
dimethylglycine dehydrogenase expression suppresses metastasis through the Akt signaling pathway
physiological function
DMGDH suppresses migration, invasion and metastasis both in vitro and in vivo. In a DMGDH over-expressing cell line, the phosphorylation of Akt-308/473 is significantly suppressed
physiological function
the enzyme suppresses metastasis in hepatocellular carcinoma
physiological function
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during the process of intestine regeneration, there are significant differences in metabolism between regenerative intestines at 3, 7, and 14 days post evisceration and normal intestines. Genes encoding betaine-aldehyde dehydrogenase, betaine-homocysteine S-methyltransferase 1, and dimethylglycine dehydrogenase are differentially expressed to regulate the levels of betaine and N,N-dimethylglycine during intestine regeneration