1.14.11.38: verruculogen synthase
This is an abbreviated version!
For detailed information about verruculogen synthase, go to the full flat file.
Reaction
Synonyms
fmtF, FmtOx1, FtmF
ECTree
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Substrates Products
Substrates Products on EC 1.14.11.38 - verruculogen synthase
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REACTION DIAGRAM
verruculogen + succinate + CO2 + H2O + A
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fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2
verruculogen + succinate + CO2 + H2O + A
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the enzyme is involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgin A
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fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2
verruculogen + succinate + CO2 + H2O + A
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fumitremorgin B i.e. (5aR,6S,12S,14aS)-5a,6-dihydroxy-9-methoxy-11-(3-methylbut-2-en-1-yl)-12-(2-methylprop-1-en-1-yl)-1,2,3,5a,6,11,12,14a-octahydro-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione. Both atoms of a dioxygen molecule are incorporated into verruculogen
verruculogen i.e. (5R,10S,10aR,14aS,15bS)-10,10a-dihydroxy-6-methoxy-2,2-dimethyl-5-(2-methylprop-1-en-1-yl)-1,10,10a,14,14a,15b-hexahydro-12H-3,4-dioxa-5a,11a,15a-triazacycloocta[1,2,3-lm]indeno[5,6-b]fluorene-11,15(2H,13H)-dione
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