1.1.99.37: methanol dehydrogenase (nicotinoprotein)
This is an abbreviated version!
For detailed information about methanol dehydrogenase (nicotinoprotein), go to the full flat file.
Word Map on EC 1.1.99.37
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1.1.99.37
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thermotolerant
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formaldehyde
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methanolicus
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rump
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methanol-limited
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decameric
- 1.1.99.37
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thermotolerant
- formaldehyde
- methanolicus
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rump
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methanol-limited
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decameric
Reaction
Synonyms
MDH, MDO, methanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase, NAD-dependent methanol dehydrogenase, NDMA-dependent methanol dehydrogenase
ECTree
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Activating Compound
Activating Compound on EC 1.1.99.37 - methanol dehydrogenase (nicotinoprotein)
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additional information
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the low coenzyme NAD-dependent activity of MDH with C1-C4 primary alcohols is strongly stimulated by Bacillus methanolicus protein ACT, in presence of NAD(H) cofactor and Mg2+-ions. In the deduced ACT amino acid sequence, the highly conserved amino acid sequence motif typical of Nudix hydrolase proteins is present. MDH activation by ACT involves hydrolytic removal of the nicotinamide mononucleotide NMN(H) moiety of the NAD(H) cofactor of MDH, changing its Ping-Pong type of reaction mechanism into a ternary complex reaction mechanism
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