1.1.98.3: decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase
This is an abbreviated version!
For detailed information about decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase, go to the full flat file.
Word Map on EC 1.1.98.3
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1.1.98.3
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tuberculosis
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mycobacterium
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antitubercular
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benzothiazinones
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antimycobacterial
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antituberculosis
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pbtz169
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arabinans
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arabinogalactan
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anti-tb
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corynebacterineae
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drug-susceptible
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xdr-tb
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1,2,3-triazole
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tca1
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dinitrobenzamides
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nitroso
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analysis
- 1.1.98.3
- tuberculosis
- mycobacterium
-
antitubercular
-
benzothiazinones
-
antimycobacterial
-
antituberculosis
- pbtz169
- arabinans
- arabinogalactan
-
anti-tb
- corynebacterineae
-
drug-susceptible
-
xdr-tb
-
1,2,3-triazole
- tca1
-
dinitrobenzamides
-
nitroso
- analysis
Reaction
Synonyms
decaprenylphospho-beta-D-ribofuranose 2-oxidase, decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase, decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase, decaprenylphosphoryl-beta-D-ribose 2'-epimerase, decaprenylphosphoryl-beta-D-ribose 2'-oxidase, decaprenylphosphoryl-beta-D-ribose 2-epimerase, decaprenylphosphoryl-beta-D-ribose oxidase, decaprenylphosphoryl-beta-D-ribose-2'-epimerase, decaprenylphosphoryl-D-ribose oxidase, DprE1, DprE2, MSMEG_6382, Rv3790
ECTree
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Engineering
Engineering on EC 1.1.98.3 - decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase
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C387G
C387N
the mutation confers resistance to benzothiazinones and reduces the overall catalytic efficiency by about 4fold compared to the wild type enzyme
C387S
C387G
C387N
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the mutation confers resistance to benzothiazinones and reduces the overall catalytic efficiency by about 4fold compared to the wild type enzyme
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C387S
C394G
benzothiazinone-resistant mutant, reduces benzothiazinones to inert metabolites while avoiding covalent inactivation
C394S
benzothiazinone-resistant mutant, reduces benzothiazinones to inert metabolites while avoiding covalent inactivation
additional information
mutation confers resistance to 1-methyl-2,4,7-trinitroxanthone and to 3-nitro-N-[(1R)-1-phenylethyl]-5-(trifluoromethyl)benzamide
C387G
the mutation confers resistance to benzothiazinones and reduces the overall catalytic efficiency by about 4fold compared to the wild type enzyme
mutation confers resistance to 1-methyl-2,4,7-trinitroxanthone and to 3-nitro-N-[(1R)-1-phenylethyl]-5-(trifluoromethyl)benzamide
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mutation confers resistance to 1-methyl-2,4,7-trinitroxanthone and to 3-nitro-N-[(1R)-1-phenylethyl]-5-(trifluoromethyl)benzamide
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C387G
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the mutation confers resistance to benzothiazinones and reduces the overall catalytic efficiency by about 4fold compared to the wild type enzyme
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-
mutation confers resistance to 1-methyl-2,4,7-trinitroxanthone and to 3-nitro-N-[(1R)-1-phenylethyl]-5-(trifluoromethyl)benzamide
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isolation of mutant strains resistant to dinitrobenzamides. All mutants show cross-resistance to benzothiazinones and dinitrobenzamides, and all the mutant strains with a higher level of resistance to dinitrobenzamides have a substitution C394G of MSMEG_6382 gene encoding decaprenylphospho-?-D-ribofuranose 2-oxidase
additional information
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isolation of mutant strains resistant to dinitrobenzamides. All mutants show cross-resistance to benzothiazinones and dinitrobenzamides, and all the mutant strains with a higher level of resistance to dinitrobenzamides have a substitution C394G of MSMEG_6382 gene encoding decaprenylphospho-?-D-ribofuranose 2-oxidase