1.1.1.312: 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
This is an abbreviated version!
For detailed information about 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.312
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1.1.1.312
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protocatechuate
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2-pyrone-4,6-dicarboxylate
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4,5-dioxygenase
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lignin
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sphingomonas
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ligab
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paucimobilis
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ochraceae
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vanillate
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4,5-cleavage
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hydratase
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syringate
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ecori
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dehydrogenases
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testosteroni
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putida
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nad+
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biotechnology
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4-oxalomesaconate
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comamonas
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oxaloacetate
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industry
- 1.1.1.312
- protocatechuate
- 2-pyrone-4,6-dicarboxylate
-
4,5-dioxygenase
- lignin
-
sphingomonas
- ligab
- paucimobilis
- ochraceae
- vanillate
-
4,5-cleavage
-
hydratase
- syringate
- ecori
- dehydrogenases
-
testosteroni
- putida
- nad+
- biotechnology
- 4-oxalomesaconate
-
comamonas
- oxaloacetate
- industry
Reaction
Synonyms
2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 2-hydroxy-4-carboxymuconate-6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase, 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase, CHMS dehydrogenase, CHMS hydrolase, dehydrogenase, 2-hydroxy-4-carboxymuconate 6-semialdehyde, EC 1.2.1.45, PmdC
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Inhibitors
Inhibitors on EC 1.1.1.312 - 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
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2-pyrone-4,6-dicarboxylic acid
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non-competitive inhibition with respect to 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde
5,5'-dithiobis(2-nitrobenzoate)
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1 h at 0.1 mM inhibits 98% of enzyme activity
methoxy Reactive Blue 2
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inhibits the enzyme non-competitively with respect to 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and competitively with respect to NADP+
Monoiodoacetic acid
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weaker inhibitor than p-chloromercuribenzoate or HgCl2
N-ethylmaleimide
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weaker inhibitor than p-chloromercuribenzoate or HgCl2
NADH
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competitive inhibition with respect to NAD+, non-competitive inhibition with respect to 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde
NADPH
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competitive inhibition with respect to NADP, non-competitive inhibition with respect to 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde
Reactive blue 2
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inhibits the enzyme non-competitively with respect to 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and competitively with respect to NADP+
Reactive Blue 4
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inhibits the enzyme non-competitively with respect to 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and competitively with respect to NADP+
additional information
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not: various metal ions, metal chelating reagents, reducing reagents
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p-chloromercuribenzoate
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1 h at 0.01 mM inhibits 78% of enzyme activity