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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203A37G naturally occurring mutation, mitochondrial disease-associated point mutations with the gene encoding mt-tRNAMet that lead to A37G substitution, impede methylation of C34 by NSUN3, lack of NSUN3-mediated modification impairs mitochondrial translation, leading to reduced mitochondrial function 756866
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203C39U naturally occurring mutation, mitochondrial disease-associated point mutations with the gene encoding mt-tRNAMet that lead to C39U substitution, impede methylation of C34 by NSUN3, lack of NSUN3-mediated modification impairs mitochondrial translation, leading to reduced mitochondrial function 756866
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203G679R site-directed mutaegensis, the mutation to arginine at this residue causes NSUN2 to fail to localize within the nucleolus 718539
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203K190M site-directed mutagenesis 718539
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203K190M site-directed mutagenesis, catalytically inactive mutant 758103
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203more combined knockdown of NSUN2 and METTL1, EC 2.1.1.33, in HeLa cells 737060
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203more generation of an insertion mutation in Drosophila NSun2 (NSun2DELTA21.5), which is viable and fertile and loses RNA methylation at known tRNA substrates. RNAi-mediated knockdown of NSun2 in follicle cells. Functional Gypsy retroviral particles can be formed in NSun2 mutants. Specific eccDNAs accumulate in RCMT mutants. RCMT mutants display reduced tRNA stability and tRNA abundance 756399
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203more generation of enzyme depeleted NSUN2-/- cells. Rescue for loss of NSUN2 by reexpressing the wild-type or enzymatic dead protein. The number of m5C per tRNA in all tRNAs or tRNA leucine is quantified by mass spectrometry in NSUN2-/- cells reexpressing wild-type NSUN2, the catalytically inactive NSUN2 K190M mutant, or the empty vector control. Reexpression of NSUN2 significantly restores 525 methylation sites when compared to the empty vector control and 431 sites when compared to K190M-overexpressing cells 758103
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203more generation of NSUN3 knockout cells. When the knockout strain is rescued by plasmid-encoded NSUN3, f5C34 in mt-tRNAMet is partially restored 757733
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203more mutation of the cysteine in motif IV in human NSUN3 to alanine or serine results in a stable covalent intermediate 756866
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