EC Number   |
Protein Variants |
Reference |
|---|
    1.1.1.213 | C217A |
resistant to inactivation by secosteroids, therefore Cys217 is the point of covalent attachment of acetylenic ketones |
347989 |
| 1.1.1.213 | D50E |
1/30th catalytic efficiency of wild type, unlikely to be the general amino acid for catalysis |
347989 |
| 1.1.1.213 | D50N |
1/30th catalytic efficiency of wild type, unlikely to be the general amino acid for catalysis |
347989 |
| 1.1.1.213 | E276R |
site-directed mutagenesis, the mutation alters the cofactor specificity of AKR1C17 from NAD+ to NADP+, the switch is analogy th the residues of AKRc9 and its cofactor specificity, overview |
684676 |
| 1.1.1.213 | F118A |
largest changes in kcat/Km |
697310 |
| 1.1.1.213 | F118A |
site-directed mutagenesis, highly reduced activity compared to the wild-type enzyme, effects of mutation on binding constants and kinetics, overview |
654756 |
| 1.1.1.213 | F129A |
largest changes in kcat/Km, F129A alters the stereochemical preference from oxidizing predominantly the S,S-stereoisomer to oxidizing predominantly the R,R-stereoisomer of benzo[g]chrysene-11,12-dihydrodiol |
697310 |
| 1.1.1.213 | F129A |
site-directed mutagenesis, highly reduced activity compared to the wild-type enzyme, effects of mutation on binding constants and kinetics, overview |
654756 |
| 1.1.1.213 | H117A |
1/500th catalytic efficiency of wild type, unlikely to be the general amino acid for catalysis |
347989 |
| 1.1.1.213 | H5Q |
a naturally occuring non-synonymous single nucleotide polymorphism (SNP), rs12529 C>G or AKR1C3-2 in exon 1 of AKR1C3 |
741389 |
