EC Number   |
Protein Variants |
Reference |
|---|
   1.1.1.149 | D309L |
similar Km-value as wild-type |
656526 |
| 1.1.1.149 | E127D |
increase in Km-value |
656526 |
| 1.1.1.149 | F311A |
mutation results in increased Ki values for 3-chloro-5-phenylsalicylic acid and 3,5-dichlorosalicylic acid compared to the wild-type enzyme |
724521 |
| 1.1.1.149 | F311L |
mutation results in equal Ki value for 3-chloro-5-phenylsalicylic acid and increased Ki value for 3,5-dichlorosalicylic acid compared to the wild-type enzyme |
724521 |
| 1.1.1.149 | H222I |
dramatic increase in Km-value |
656526 |
| 1.1.1.149 | H222S |
large increase in Km-value |
656526 |
| 1.1.1.149 | H222S |
the mutation in AKR1C1 results in a 10fold reduction in the potency of the inhibitor 3,5-dicholorosalicylic acid |
699437 |
| 1.1.1.149 | L306 |
the mutation in AKR1C1 results in a 46fold reduction in the potency of the inhibitor 3,5-dicholorosalicylic acid |
699437 |
| 1.1.1.149 | L306A |
mutation results in 81fold increase Ki values for 3-chloro-5-phenylsalicylic acid compared to the wild-type enzyme |
724521 |
| 1.1.1.149 | L308A |
mutation renders the enzyme inactive towards the two substrates 5alpha-pregnane-3alpha,20alpha-diol and 5beta-pregnan-3alpha-ol-20-one |
711423 |
