EC Number   |
|---|
    1.1.1.205 | analysis of crystal structures. The Cys319 loop has different conformations during the dehydrogenase and hydrolase reactions as suggested by the crystal structures. The structure of the Cys319 loop modulates the closure of themobile flap. This conformational change converts the enzyme from a dehydrogenase into hydrolase, suggesting that the conformation of the Cys319 loop may gate the catalytic cycle |
| 1.1.1.205 | apoenzyme and enzyme in complex with 18, hanging drop vapor diffusion method, using 500 mM lithium chloride, 50 mM ammonium sulfate and 8% (w/v) PEG 8000 |
| 1.1.1.205 | at 2.18 A resolution |
| 1.1.1.205 | at 2.3 A resolution, in complex with inosine 5'-phosphate and beta-methylene-thiazole-4-carboxyamide-adenine dinucleotide at 2.2 A resolution, in complex with xanthosine 5'-phosphate and NAD+ at 2.15 A resolution, in complex with xanthosine 5'-phosphate and mycophenolic acid at 2.2 A resolution, in complex with RVP and mycophenolic acid at 2.15 A resolution, in complex with 4-carbamoyl-1-beta-D-ribofuranosylimidazolium-5-olate-5'-phosphate at 2.0 A resolution |
| 1.1.1.205 | at 2.4 A resolution |
| 1.1.1.205 | enzyme in complex with Ap5G and GDP, vapor diffusion method, using 20% (w/v) PEG-6000, 0.1 M sodium acetate, pH 5.0, 0.2 M sodium chloride |
| 1.1.1.205 | enzyme in complex with ATP, vapor diffusion method, using 0.02 M D-glucose, 0.02 M D-mannose, 0.02 M D-galactose, 0.02 M L-sucrose, 0.02 M D-xylose,0.02 M N-acetyl-D-glucosamine, 0.05 M imidazole, 0.05 M MES, pH 6.5, 20% (w/v) glycerol, 20% (w/v) PEG-4000. Enzyme in complex with ATP/GDP, vapor diffusion method, using 0.1 M lithium acetate, 0.1 M Bis-Tris pH 6.0, 20% (w/v) Sokolan-CP42 |
| 1.1.1.205 | enzyme in complex with oxanosine monophosphate, sitting drop vapor diffusion method, using 0.1 M lithium sulfate, 0.1 MES, pH 6.0, and 35% (v/v) 2-methyl-2,4-pentanediol |
| 1.1.1.205 | enzyme in complex with oxanosine monophosphate, sitting drop vapor diffusion method, using 0.1 M magnesium chloride, 0.1 M MES, pH 6.5, and 30% (v/v) PEG 400 |
| 1.1.1.205 | enzyme type II complexed with 6-Cl-IMP and selenazole-4-carboxamide adenine dinucleotide, no method mentioned |
