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Results 1 - 7 of 7
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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the reaction diagram Show all sequences 2.4.1.B46dTDP-2-deoxy-alpha-L-fucose + 4-O-[(4-O-2-deoxy-alpha-L-fucosyl)-alpha-L-rhodosaminyl]aklavinone AknK also catalyzes a tandem addition of a second L-2-deoxyfucosyl moiety, albeit with reduced activity, to the natural disaccharide chain to produce L-deoxyfucosyl-L-deoxyfucosyl-L-rhodosaminyl aklavinone, a variant of the natural aclacinomycin A. The second transfer reaction is 3 orders of magnitude slower than the first sugar transfer reaction catalyzed by AknK Streptomyces galilaeus dTDP + 4-O-[[4-O-2-deoxy-alpha-L-fucosyl-(4-O-alpha-L-2-deoxyfucosyl)]alpha-L-rhodosaminyl]aklavinone - ?
Display the reaction diagram Show all sequences 2.4.1.B46dTDP-2-deoxy-alpha-L-fucose + 4-O-[(4-O-2-deoxy-alpha-L-fucosyl)-alpha-L-rhodosaminyl]aklavinone - Streptomyces galilaeus dTDP + 4-O-[[4-O-alpha-L-2-deoxyfucosyl-(4-O-2-deoxy-alpha-L-fucosyl)]alpha-L-rhodosaminyl]aklavinone - ?
Display the reaction diagram Show all sequences 2.4.1.B46dTDP-2-deoxy-alpha-L-fucose + idarubicin - Streptomyces galilaeus dTDP + 4'-O-(2-deoxy-alpha-L-fucosyl)idarubicin - ?
Display the reaction diagram Show all sequences 2.4.1.B46dTDP-2-deoxy-beta-L-fucose + 4-O-(alpha-L-rhodosaminyl)aklavinone - Streptomyces galilaeus dTDP + 4-O-[(4-O-2-deoxy-alpha-L-fucosyl)-alpha-L-rhodosaminyl]aklavinone - ?
Display the reaction diagram Show all sequences 2.4.1.B46dTDP-L-daunosamine + 4-O-(alpha-L-rhodosaminyl)aklavinone the enzyme accepts L-daunosamine as an alternative sugar substrate, albeit with a 270fold decrease in catalytic efficiency (kcat/Km) Streptomyces galilaeus dTDP + 4-O-[(4-O-alpha-L-daunosaminyl)-alpha-L-rhodosaminyl]aklavinone - ?
Display the reaction diagram Show all sequences 2.4.1.B46more AknK also accepts an alternate dTDP-L-sugar, dTDP-L-daunosamine, and other monoglycosylated anthracyclines, including daunomycin, adriamycin, and idarubicin, to build alternate disaccharides on variant anthracycline backbones Streptomyces galilaeus ? - ?
Display the reaction diagram Show all sequences 2.4.1.B46more the enzyme does not transfer TDP-L-rhodosamine Streptomyces galilaeus ? - ?
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