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EC Number	General Information	Commentary	Reference
2.6.1.121	physiological function	enzyme is involved in biotin biosynthesis. BioU catalyzes three reactions: formation of covalent linkage with 8-amino-7-oxononanoate to yield a BioU-7,8-diaminononanoate conjugate at the epsilon-amino group of Lys124 of BioU using NAD(P)H, carboxylation of the conjugate to form BioU-7,8-diaminononanoate-carbamic acid, and release of 7,8-diaminononanoate-carbamic acid using NAD(P)+. In this biosynthetic pathway, BioU is a suicide enzyme that loses the Lys124 amino group after a single round of reaction	763493

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Release 2023.1 (January 2023)