EC Number   |
General Information |
Reference |
|---|
    2.4.2.30 | malfunction |
disruption of PARP1 enzymatic activity causes nucleolar disintegration and aberrant localization of nucleolar-specific proteins. PARP1 mutants have increased accumulation of rRNA intermediates and a decrease in ribosome levels |
723512 |
| 2.4.2.30 | malfunction |
enzyme deletion results in teratozoospermia and male infertility in mice due to the formation of abnormally shaped fertilization-incompetent sperm, despite normal testis weights and sperm counts |
735741 |
| 2.4.2.30 | malfunction |
enzyme knockdown results in genomic instability and DNA damage hypersensitivity |
736446 |
| 2.4.2.30 | malfunction |
enzyme loss induces higher levels of cytokine production and downregulates ex-vivo apoptosis of splenocytes |
736818 |
| 2.4.2.30 | metabolism |
enzyme-induced ADP-ribosylation regulates multiple nonreceptor tyrosine kinases in vivo |
759710 |
| 2.4.2.30 | metabolism |
the enzyme inhibits the activation of NF-kappaB and downstream target genes in response to interleukin-1beta and tumour necrosis factor-alpha, dependent on catalytic activity and poly-ubiquitin binding |
736869 |
| 2.4.2.30 | metabolism |
the enzyme PARP14 is an important modulator of the response to ATR-CHK1 pathway inhibitors |
759864 |
| 2.4.2.30 | metabolism |
the lowest PARP activity, as well as the lowest quantum yield of PSII linear electron transport (FPSII) and photochemical quenching (qP), is found in outdoor during winter plants. In outdoor spring plants the recovery of photochemical activity associated to a poly(ADP-ribose)polymerase activity increase of about 50%, as compared to greenhouse plants, is observed |
723446 |
| 2.4.2.30 | physiological function |
enzyme binding to human epithelial cells leads to protein internalization, impairs human epithelial monolayer integrity, induces cell rounding, and impacts on actin cytoskeleton |
737081 |
| 2.4.2.30 | physiological function |
enzyme binding to proliferating cell nuclear antigen is required for translesion DNA synthesis. The enzyme is required for genomic stability, DNA damage tolerance and mutagenesis |
736446 |
