EC Number   |
General Information |
Reference |
|---|
   2.1.1.B109 | malfunction |
deletion of the actin-binding sequence in ABP140 does not affect m3C formation. The yor240wDELTA strain, lacking the half of gene ABP140, hatbors tRNAs Ser and Thr that are not m3C methylated, mass spectrometric aanalysis |
-, 721028 |
| 2.1.1.B109 | malfunction |
specific reduction of m3C formation in HeLa cells by siRNA-mediated knockdown of the human orthologue of TRM14 |
721028 |
| 2.1.1.B109 | more |
some partner proteins of METTL2B might be required to reconstitute m3C formation in tRNAs |
721028 |
| 2.1.1.B109 | more |
subcellular localization of ABP140 to actin filaments is not involved in tRNA modification |
-, 721028 |
| 2.1.1.B109 | physiological function |
methyl modification of m3C32 might modulate accurate codon recognition at the A-site and the proper ribosomal positioning at the P-site. Abp140p interacts with filamentous actin and has an activity to cross-link F-actin into a bundle in vitro. In the cell, Abp140p colocalizes with cortical actin patches and cytoplasmic actin filaments, but it is not required for cell growth or organization of F-actin |
-, 721028 |
