EC Number   |
General Information |
Reference |
|---|
    1.1.1.205 | evolution |
classification of bacterial IMPDHs according to the regulation of their catalytic properties and their quaternary structures. Class I IMPDHs are cooperative enzymes for IMP, which are activated by MgATP and are octameric in all tested conditions. On the other hand, class II IMPDHs behave as Michaelis-Menten enzymes for both substrates and are tetramers in their apo state or in the presence of IMP, which are shifted to octamers in the presence of NAD+ or MgATP |
-, 741229 |
| 1.1.1.205 | evolution |
classification of bacterial IMPDHs according to the regulation of their catalytic properties and their quaternary structures. Class I IMPDHs are cooperative enzymes for IMP, which are activated by MgATP2- and are octameric in all tested conditions. On the other hand, class II IMPDHs behave as Michaelis-Menten enzymes for both substrates and are tetramers in their apo state or in the presence of IMP, which are shifted to octamers in the presence of NAD+ or MgATP2- |
-, 741229 |
| 1.1.1.205 | evolution |
comparison of enzyme activity and purine metabolite concentration in erythrocytes and plasma from a non-diving mammal (domestic pig) than from diving mammals (river otter and northern elephant seal). IMPDH activity in erythrocytes from domestic pig, Sus scrofa, is higher than that of erythrocytes from river otter, Lontra longicaudis annectens, and northern elephant seal, Mirounga angustirostris. IMPDH activities as well as HX, IMP, XMP and guanine (GDP and GTP), and adenine (AMP, ADP and ATP) nucleotides concentrations in plasma and erythrocytes from diving mammals are lower than those from a non-diving mammal |
736152 |
| 1.1.1.205 | malfunction |
a guanine-prototrophic Escherichia coli strain, MP101, is constructed with the cystathionine beta-synthase subdomain deleted from the chromosomal gene for IMPDH. The ATP content is substantially elevated in mutant strain MP101 whereas the GTP content is slighty reduced. The activities of IMPDH, adenylosuccinate synthetase and GMP reductase are 2 to 3fold lower in MP101 crude extracts compared with wild-type strain. Results of a comparative analysis of the purine nucleotide pools, fluxes and turnover rates in the mutant and wild-type strains, indicate that the cystathionine beta-synthase subdomain of IMPDH plays an important role in the regulation of purine nucleotide metabolism |
689055 |
| 1.1.1.205 | malfunction |
defects in inosine monophosphate dehydrogenase-1 lead to insufficient biosyntheses of purine nucleotides and are believed to cause retinitis pigmentosa in eyes |
760826 |
| 1.1.1.205 | malfunction |
enzyme depletion is bactericidal in vitro and ex vivo |
-, 760262 |
| 1.1.1.205 | malfunction |
enzyme dysfunction leads to retinitis pigmentosa |
761406 |
| 1.1.1.205 | malfunction |
IMPDH enzyme deletion leads to suppression of the glycolytic pathway enzymes triosephosphate isomerase (TPI) and glyceraldehyde phosphate dehydrogenase (GAPDH). The adhesion to host cells is the crucial step to cause infection for the pathogen, and reduction of adhesion of the IMPDH deletion mutant strain to some extent causes the attenuated virulence of the IMPDH deletion mutant strain in pigs, reduced adhesion ofthe mutant strain to PK15 and HEp-2 cells |
-, 740342 |
| 1.1.1.205 | malfunction |
IMPDH inhibitors ribavirin and mycophenolic acid prevents cell growth and generates an apoptosis-like phenotype in sub-populations of L.eishmania amazonensis promastigotes. A subpopulation of parasites undergoes apoptosislike cell death in the nutrient poor environment of the vector gut |
740417 |
| 1.1.1.205 | malfunction |
inhibition of IMPDH causes an overall reduction in guanine nucleotide pools and, as phosphoribosyl pyrophosphate (PRPP) synthetase and ribonucleotide reductase are allosterically regulated by these nucleotides, it may affect several metabolic pathways |
-, 741400 |
