EC Number   |
Application |
Reference |
|---|
    1.4.3.22 | analysis |
the enzyme can be used as biocatalytic component of an electrochemical biosensor for the determination of biogenic amines index in wine and beer samples |
723927 |
| 1.4.3.22 | biotechnology |
supramolecular tandem assays exploit the dynamic binding of a fluorescent dye with a macrocyclic host in competition with the binding of the substrate and product. Two examples of enzymatic reactions were investigated: the hydrolysis of arginine to ornithine catalyzed by arginase and the oxidation of cadaverine to 5-aminopentanal by diamine oxidase, in which the substrates have a higher affinity to the macrocycle than the products (substrate-selective assays). The depletion of the substrate allows the fluorescent dye to enter the macrocycle in the course of the enzymatic reaction, which leads to the desired fluorescence response. For arginase, p-sulfonatocalix[4]arene is used as the macrocycle, and for diamine oxidase, cucurbit[7]uril (CB7) is used. An additional reporter pair, namely cucurbit[7]uril (CB7)/acridine orange (AO) is applied and the potential of tandem assays for inhibitor screening is demonstrated |
704175 |
| 1.4.3.22 | diagnostics |
a research prototype ELISA is able to reliably and accurately quantify the human enzyme in different biological fluids. The potential of diamine oxidase as biomarker in various diseases can be evaluated |
764513 |
| 1.4.3.22 | diagnostics |
clinical impact of a commercial radioimmunoassay for determination of DAO activity for the diagnosis of histamine intolerance is evaluated in a prospective, multicentre study in 207 adult patients. No correlation between diamine oxidase serum levels and clinical status is be found |
701603 |
| 1.4.3.22 | food industry |
degradation of biogenic amines |
-, 765126 |
| 1.4.3.22 | medicine |
determination of fresh plasma diamine oxidase activity may serve as an effective tool to diagnose Cu deficiency in the bovine |
687323 |
| 1.4.3.22 | medicine |
excess of histamine in gut lumen generates a pronounced gastrointestinal discomfort, which may include diarrhea and peristalsis dysfunctions. Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles |
765780 |
| 1.4.3.22 | medicine |
histaminase exerts a clear-cut protective effect in splanchnic artery occlusion/reperfusion-induced splanchnic injury, likely caused by oxidative catabolism of proinflammatory histamine and antioxidant effects resulting in hindrance of free radicalYmediated tissue injury, endothelial dysfunction, and leukocyte recruitment. Histaminase could be used therapeutically in intestinal ischemia |
690074 |
| 1.4.3.22 | medicine |
the balance between histamine and DAO seems to be crucial for an uncomplicated course of pregnancy. Reduced DAO activities are found in multiple heterogeneous complications of pregnancy such as diabetes, threatened and missed abortion and trophoblastic disorders. Low activities of the histamine-degrading enzyme DAO might indicate high-risk pregnancies, although high intra- and interindividual variations limit its value as a screening tool |
687047 |
| 1.4.3.22 | pharmacology |
formulation of vegetal diamine oxidase as a food supplement for the prevention of food allergy and treatment of enteric dysfunction. Study on the stability of diamine oxidase, purified from Lathyrus sativus seedlings, in various simulated intestinal media is reported. The catalytic activity of different diamine oxidase concentrations is tested in simulated intestinal media with different pH and containing cholic acids, pancreatic bicarbonate, and proteases or exogenous food- and drink-derived items, such as lipids or alcohol, alone or in combination |
764948 |
