EC Number   |
Application |
Reference |
|---|
   1.2.3.1 | degradation |
aldehyde oxidase plays a critical role in nitrite reduction, and this process is regulated by pH, oxygen tension, nitrite, and reducing substrate concentrations |
693075 |
| 1.2.3.1 | degradation |
the enzyme plays a dual role in the metabolism of physiologically important endogenous compounds and the biotransformation of xenobiotics. Simple qualitative method using density functional theory to predict the product of aldehyde oxidase metabolism by examining the energetics of likely tetrahedral intermediates resulting from nucleophilic attack on carbon |
693533 |
| 1.2.3.1 | medicine |
3-substituted quinoline triazolopyridine compounds used as c-Met kinase inhibitors are subject to aldehyde oxidase-mediated metabolism. Several compouinds are unstable in monkey liver cytosolic incubations. Small electron-donating groups at the 3-quinoline moiety make the analogs more susceptible to metabolism, whereas large 3-substituents may reverse the trend |
762959 |
| 1.2.3.1 | medicine |
adiponectin and fenobibric acid reduce enzyme isoform AOX1 by activating peroxisome proliferator-activated receptor alpha whereas fatty liver disease is associated with elevated hepatic AOX1 level |
671778 |
| 1.2.3.1 | medicine |
aldehyde oxidase activity in rats estimated on the basis of benzaldehyde, N1-methylnicotinamide and methotrexate oxidase activities rapidly increases from birth, reaching a plateau within 4 weeks, and is regulated by expression of the protein. Aldehyde oxidase plays an important role in metabolizing many drugs that may be administered to pediatric patients. Developmental changes are important for the clinical application in infants of methotrexate and other drugs that are detoxified by aldehyde oxidase |
692051 |
| 1.2.3.1 | medicine |
aldehyde oxidase can be an important basal source of superoxide that will be enhanced in disease settings where cellular aldehyde levels are increased |
690612 |
| 1.2.3.1 | medicine |
aldehyde oxidase plays an important role in metabolizing many drugs, so aldehyde oxidase activity in individual patients may be a useful parameter for dose adjustment to avoid severe toxicity. Aldehyde oxidase activity is immature in children below 1 year of age, dose adjustment based on individual aldehyde oxidase activity shall be made for such patients |
691884 |
| 1.2.3.1 | medicine |
aldehyde oxidases represent an important drug-metabolizing system in the cytosol of the hepatic cell. AOX1 is potentially useful in the bioactivation of pro-drugs in human liver and lung, given that the two tissues are the only ones reported to express significant amounts of this enzymatic activity. Variability in the levels of liver aldehyde oxidase in the human population |
691701 |
| 1.2.3.1 | medicine |
AOX1 may affect plasma HDL levels by altering ATP-binding cassette transporter A1 activity |
692568 |
| 1.2.3.1 | medicine |
combined computational and experimental investigation of drug-like molecules that are potential aldehyde oxidase substrates and identification of multiple sites of metabolism mediated by AOX |
740850 |
