EC Number   |
Application |
Reference |
|---|
    1.1.1.205 | analysis |
real-time reverse-transcription PCR assay for mRNA quantification of isoforms IMPDH1 and IMPDH2 in blood samples and cultured cells. Limits of detection and quantification are 10 and 1000 copies of cDNA per reaction, respectively |
686145 |
| 1.1.1.205 | diagnostics |
IMPDH activity is measured in adults without thiopurine treatment as well as in adult and paediatric patients treated with thiopurines. A wide interindividual variability in IMPDH activity in erythrocytes is observed. No difference in IMPDH activity is found between untreated subjects and adult and paediatric patients on thiopurine therapy. The method described is useful in the determination of IMPDH phenotype from patients on thiopurine therapy and in the investigation of the potential relationship between IMPDH activity in erythrocytes and the occurrence of adverse events and drug response variability |
740801 |
| 1.1.1.205 | drug development |
1,2,3-triazole IMPDH inhibitors provide new tools for elucidating the role of IMPDH in Cryptosporidium parvum and may serve as potential therapeutics for treating cryptosporidiosis |
705042 |
| 1.1.1.205 | drug development |
at therapeutic concentrations in organ transplant patients, the effect of mycophenolic acid-acyl-glucuronide on IMPDHII activity is minimal compared to mycophenolic acid, and the quantification of mycophenolic acid metabolites for mycophenolate therapeutic drug monitoring and dose adjustment will be of no benefit |
703271 |
| 1.1.1.205 | drug development |
differences between the human and Mycobacterium tuberculosis IMPDHs in the region of binding of nucleotide inhibitors on the inosine 5'-phosphate binding site. These and other differences, may be exploited for the design of new inhibitors with selectivity against Mycobacterium tuberculosis IMPDH |
705494 |
| 1.1.1.205 | drug development |
IMPDH from Mycobacterium tuberculosis (MtIMPDH) is a potential molecular target to inhibitor development |
-, 741400 |
| 1.1.1.205 | drug development |
IMPDH2 is the major target for cancer chemotherapy |
703193 |
| 1.1.1.205 | drug development |
inosine 5'-monophosphate dehydrogenase 2 (IMPDH2) from Mycobacterium tuberculosis is an attractive drug target |
-, 741245 |
| 1.1.1.205 | drug development |
Roche total mycophenolic acid assay (a new inosine monophosphate dehydrogenase inhibition assay) is a promising alternative for mycophenolic acid quantification where chromatographic methods are not available |
706815 |
| 1.1.1.205 | drug development |
the enzyme IMPDH is a promising target for the treatment of Cryptosporidium infections |
-, 739820 |
