EC Number |
Natural Substrates |
---|
2.3.1.42 | acyl-CoA + glycerone phosphate |
- |
2.3.1.42 | acyl-CoA + glycerone phosphate |
enzyme is essential for biosynthesis of plasmalogens and nonetherlipids, the peroxisomal isozymes does not contribute to nonetherlipid biosynthesis |
2.3.1.42 | acyl-CoA + glycerone phosphate |
enzyme is involved in biosynthesis of plasmalogens, regulating enzyme |
2.3.1.42 | dihydroxyacetone phosphate + acyl-CoA |
- |
2.3.1.42 | dihydroxyacetone phosphate + acyl-CoA |
the enzyme performs the initial and obligatory step in the biosynthesis of ether lipids in most organisms that synthesize alkylglycerolipids and is important for rapid growth and survival at high cell density and essential for virulence, overview, lack of DAT causes a major alteration in parasite division during the logarithmic phase of growth, an accelerated cell death during stationary phase, and loss of virulence in mice |
2.3.1.42 | more |
enzyme activity is reduced with disorders: neonatal adrenoleukodystrophy, infantile Refsum disease, and hyperpipecolic acidemia |
2.3.1.42 | more |
enzyme amount is reduced by 90% in Zellweger syndrome |
2.3.1.42 | more |
patients affected with rhizomelic chondrodysplasia punctata show reduced enzyme activity due to a defect in peroxisomal targeting |
2.3.1.42 | more |
the enzyme is involved in the first step of plasmalogen biosynthesis, overview |
2.3.1.42 | palmitoyl-CoA + dihydroxyacetone phosphate |
- |